Acupuncture

Evidence Reviewed as of before: 11-08-2017
Author(s)*: Tatiana Ogourtsova, PhD(c) OT; Marc-André Roy, MSc; Nicol Korner-Bitensky, PhD; Robert Teasell, MD; Norine Foley, BASc; Sanjit Bhogal, MSc; Jamie Bitensky, MSc OT; Mark Speechley, MD; Annabel McDermott, OT
Patient/Family Information Table of contents

Introduction

Acupuncture is an ancient Chinese therapy involving the stimulation of specific trigger points along the body’s 18 meridian lines to help regulate the flow of Qi (energy). The meridian lines represent the normal flow of Qi through the body. It is believed that when this energy is disrupted, disease ensues. The use of thin metal needles or other acupuncture techniques is proposed to conduct Qi through its correct paths. The trigger points used are areas of the skin where Qi flows close to the surface and thus can be reached by the various acupuncture therapies.

While the exact mechanisms are not well defined in terms of Western medicine, there are biological responses that occur directly at the stimulus point and indirectly at other parts of the body. In addition to the use of fine needles, other methods of acupuncture include:

  • electro-acupuncture (current through the needles),
    L'électro-acupuncture
    Pictures courtesy of Ricardo Miranda,L.Ac
  • cupping (suction cups on trigger points),
    les ventouses
    Pictures courtesy of Ricardo Miranda,L.Ac
  • acupressure using trigger points (applying pressure with fingers or instruments),
  • reflexology (using pressure on the soles of the feet and inferior ankle to stimulate various parts of the body),
  • moxibustion (heat at trigger points, often combined with needles),la moxibustion
    la moxibustion
    Pictures courtesy of Ricardo Miranda,L.Ac
  • auriculotherapy (stimulating trigger points on the ear to affect other parts of the body),
  • laserpuncture and sonopuncture (using sound waves over trigger points).

Acupuncture has been used to treat many types of health problems and in the past decade has been advocated by some for the treatment of stroke. Recently, a number of studies have explored the use of acupuncture in stroke rehabilitation.

Patient/Family Information

Author: Tatiana Ogourtsova, PhD(c) OT, Marc-André Roy, MSc

What is acupuncture?

Acupuncture comes from ancient Chinese medicine. It has been used to treat pain in China for about 3000 years. The Chinese explanation involves Qi (pronounced Chee), an energy that flows through the body. The belief is that when this Qi is balanced (Yin and Yang), then the body is healthy. Qi flows through different lines within your body called “meridians”. With the most common form of acupuncture, an expert puts very small needles into specific areas of your body where Qi flows close to the surface of the skin.

There is some evidence that acupuncture works after operations to stop pain, after chemotherapy to stop feeling sick and vomiting, during pregnancy to stop feeling sick and after dental surgery for dental pain. It has also been used to treat headaches, tennis elbow, fibromyalgia (general muscle pain), low back pain, carpal tunnel syndrome and asthma.

While we are not sure exactly how it works, 3 possible explanations have been given:

  • Acupuncture blocks pain from traveling in your nerves
  • Acupuncture causes your body to make chemicals that prevent pain
  • Acupuncture opens or closes your veins and arteries in important areas of the body

Are there different kinds of acupuncture?

The most popular acupuncture is performed by putting thin metal needles into the skin. Other forms of acupuncture include:

  • electro-acupuncture, which again uses needles through which very small electrical currents are passed;L'électro-acupuncturePictures courtesy of Ricardo Miranda,L.Ac
  • auriculotherapy, which uses either needles or pressure on different spots of the ear which are trigger points for the entire body;
  • moxibustion, which uses heat at different spots on the body;moxibustion moxibustionPictures courtesy of Ricardo Miranda,L.Ac
  • sonopuncture, which uses sound waves at different spots on the body
  • cupping, which uses suction cups over areas such as the back or the legs to pull blood and other fluids in the area under the skin;cuppingPictures courtesy of Ricardo Miranda,L.Ac
  • acupressure, which uses pressure on different spots on the body;
  • reflexology, which uses pressure under the feet or the back part of the ankles.

Why use acupuncture after a stroke?

Acupuncture has been used after a stroke to treat spasticity (stiffness of muscles caused by the stroke), loss of function, loss of mobility, depression, aphasia (loss of speaking and writing skills), hemiplegia (loss of feeling and/or power to move one side of the body) and for pain reduction.

Does it work for stroke?

Experts have done some experiments to compare acupuncture with other treatments to see whether acupuncture helps people who have had a stroke.

In individuals with ACUTE stroke (< 4 weeks after stroke)
Thirteen high quality studies and 7 fair quality studies found that acupuncture:

  • Was not more helpful than other treatments for improving cognitive skills (e.g. memory, language); mood (e.g. depression); self-care skills (e.g. dressing, shopping); quality of life; physical skills (e.g. strength, range of motion, sensation, motor function of arms and legs); or mobility (e.g. balance, walking speed); but
  • Was more helpful than the usual treatment for improving swallowing skills and swallowing safety.

In individuals with SUBACUTE stroke (1 to 6 months after stroke)
One high quality study found that acupuncture:

  • Was not more helpful than pretend acupuncture for improving range of motion.

In individuals with CHRONIC stroke (> 6 months after stroke)
Three high quality studies and 1 low quality study found that acupuncture:

  • Was not more helpful than pretend acupuncture for improving mood (e.g. depression); self-care skills (e.g. dressing); mobility (e.g. walking endurance); physical skills (e.g. spasticity, range of motion, strength) or pain.

What can I expect?

Most people find that having acupuncture treatment causes very little pain, if any. In most cases you feel the needle going in, but it doesn’t hurt. Some people say they feel cramping, heaviness or tingling at the needle site or up the “meridian”.

The acupuncturist may use other treatments once the needles are in place. This depends on his/her training.

Side effects/risks?

As with any other use of needles, sanitation is very important to not spread germs. All acupuncturists should use new, individually packaged, disposable needles. If these are not used, don’t agree to treatment.

There is little risk related to acupuncture if done by a qualified professional. Side effects could include dizziness, feeling sick and feeling tired after treatment. There could also be a little bleeding at the needle site and some slight bruising. There is always a slight risk of infection when putting needles in the skin.

Who provides the treatment?

Acupuncture should be performed by a trained health professional. A variety of health professionals provide acupuncture as part of their treatment including doctors and physical therapists. Individuals known as acupunturists only use acupuncture as their main treatment.

How many treatments?

This depends on the reason you are getting acupuncture. You should discuss the treatment plan with the acupuncturist before starting treatment. You might receive anywhere from one to 15 treatment sessions.

How much does it cost? Does insurance pay for It?

Acupuncture is not paid for by provincial insurance plans. However, it is covered by some private insurance plans. The cost for each session may vary from $40.00 to $90.00.

Is acupuncture for me?

Although the benefits of acupuncture have been talked about for hundreds of years, there is no strong scientific evidence that it works to reduce spasticity, loss of function, loss of mobility, depression, aphasia or pain. Yet, there are some people who say they have found it helpful.

Clinician Information

Note: When reviewing the findings, it is important to note that they are always made according to randomized clinical trial (RCT) criteria – specifically as compared to a control group. To clarify, if a treatment is “effective” it implies that it is more effective than the control treatment to which it was compared. Non-randomized studies are no longer included when there is sufficient research to indicate strong evidence (level 1a) for an outcome.

The current module includes 35 RCTs including 25 high quality RCTs, nine fair quality RCTs and one poor quality RCT. Numerous outcome measures were used throughout studies and outcomes include balance, cognitive function, dexterity, depression, functional independence, motor function, quality of life, swallowing function, etc. Studies conducted with patients in one phase of stroke recovery, be it the acute, subacute, or chronic phases of stroke recovery, predominantly reported that acupuncture was not more effective than comparison interventions in improving most outcomes (with the exception of dysphagia and swallowing function). By comparison, studies that included patients across stages of stroke recovery (e.g. patients in the acute or subacute phases of stroke recovery) generally reported that acupuncture was more effective than comparison interventions in improving outcomes (especially those related to cognitive function, health related quality of life, insomnia, mobility and swallowing function).

Results Table

View results table

Outcomes

Acute Phase

Balance
Not effective
1b

One high quality RCT (Hsieh et al., 2007) and one fair quality RCT (Johansson et al., 1993) investigated the effect of acupuncture on balance in patients with acute stroke.

The high quality RCT (Hsieh et al., 2007) randomized patients to receive electroacupuncture or no acupuncture; both groups received conventional rehabilitation. Balance was measured by the Fugl-Meyer Assessment (FMA – Balance) during treatment (2 weeks), at post-treatment (4 weeks), and follow-up (3 and 6 months post-stroke). No significant between-group differences were found at any time point.

The fair quality RCT (Johansson et al., 1993) randomized patients to receive electroacupuncture or no acupuncture; both groups received conventional rehabilitation. Balance was measured by the modified Chart for Motor Capacity Assessment – Balance at mid-treatment (1 month post-stroke), and follow-up (3 months post-stroke); measures were not taken at post-treatment (10 weeks). Significant between-group differences were found at both time points, favoring electroacupuncture vs. no acupuncture.

Conclusion: There is moderate evidence (Level 1b) from one high quality RCT that acupuncture is not more effective than a comparison intervention (conventional rehabilitation with no acupuncture) in improving balance in patients with acute stroke.
Note: 
However, one fair quality RCT found that acupuncture was more effective than no acupuncture in improving balance in patients with acute stroke; the studies differed in duration of the intervention (4 weeks vs. 10 weeks) and outcome measures used to assess balance.

Cognitive function
Not effective
1a

Two high quality RCTs (Rorsman & Johansson, 2006Chen et al., 2016) investigated the effect of acupuncture on cognitive function in patients with acute stroke.

The first high quality RCT (Rorsman & Johansson, 2006) randomized patients to receive acupuncture (including electroacupuncture), high intensity/low frequency transcutaneous electrical nerve stimulation TENS) or low intensity (subliminal)/high frequency TENS. Cognitive function was measured by the Mini-Mental State Examination (MMSE) at follow-up (3 and 12 months post-stroke); measures were not taken at post-treatment (10 weeks). No significant between-group differences were found at either time point.

The second high quality RCT (Chen et al., 2016) randomized patients to receive electroacupuncture or no acupuncture; both groups received conventional rehabilitation. Cognitive function was measured by the MMSE and the Montreal Cognitive Assessment (MOCA) at baseline, at post-treatment (3 weeks) and at follow-up (7 weeks). There were no significant between-group differences on either measure at post-treatment. There were significant differences in change scores on both measures from baseline to follow-up, favoring acupuncture vs. no acupuncture.

Conclusion: There is strong evidence (Level 1a) from 2 high quality RCTs that acupuncture is not more effective than comparison interventions (TENS, conventional rehabilitation with no acupuncture) for improving cognitive function in patients with acute stroke.
Note: 
However, one of the high quality RCTs reported gains in favour of acupuncture at follow-up.

Depression
Not effective
1b

One high quality RCT (Rorsman & Johansson, 2006) investigated the effect of acupuncture on depression in patients with acute stroke. The high quality RCT randomized patients to receive acupuncture (including electroacupuncture), high intensity/low frequency TENS or low intensity (subliminal)/high frequency TENS. depression was measured at follow-up (3- and 12-months post-stroke) by the Hospital Anxiety and depression Scale and the Comprehensive Psychiatric Rating Scale; measures were not taken at post-treatment (10 weeks). No significant between-group differences were found on either measure at either follow-up time point.

Conclusion: There is moderate evidence (Level 1b) from one high quality RCT that acupuncture is not more effective than comparison interventions (high intensity/low frequency TENS, low intensity/high frequency TENS) in improving depression in patients with acute stroke.

Dexterity
Not effective
1a

Two high quality RCTs (Johansson et al., 2001Park et al., 2005) investigated the effect of acupuncture on dexterity in patients with acute stroke.

The first high quality RCT (Johansson et al., 2001) randomized patients to receive electroacupuncture, high intensity/low frequency TENS or low intensity (subliminal)/high frequency TENS; all groups received conventional rehabilitation. Dexterity was measured by the Nine Hole Peg Test (NHPT) at follow-up (3 and 12 months post-stroke); measures were not taken at post-treatment (10 weeks). No significant between group differences were found at either follow-up time point.

The second high quality RCT (Park et al., 2005) randomized patients to receive manual acupuncture or sham acupuncture. Dexterity was measured by the NHPT at post-treatment (2 weeks). No significant between-group differences were found.

Conclusion: There is strong evidence (Level 1a) from two high quality RCTs that acupuncture is not more effective than comparison interventions (TENS, sham acupuncture) in improving dexterity in patients with acute stroke.

Dysphagia
Effective
1b

One high quality RCT (Xia et al., 2016) investigated the effect of acupuncture on functional severity of dysphagia in patients with acute stroke and subsequent dysphagia. This high quality RCT randomized patients to receive acupuncture or no acupuncture; both groups received standard swallowing training. Functional severity of dysphagia was measured by the Dysphagia Outcome and Severity Scale at post-treatment (4 weeks). Significant between-group differences were found, favoring acupuncture vs. no acupuncture.

Conclusion: There is moderate evidence (Level 1b) from one high quality RCT that swallowing training with acupuncture is more effective than a comparison intervention (swallowing training with no acupuncture) in improving functional severity of dysphagia in patients with acute stroke and subsequent dysphagia.

Functional independence
Not effective
1a

Ten high quality RCTs (Gosman-Hedstrom et al., 1998Johansson et al., 2001Sze et al., 2002Park et al., 2005Hsieh et al., 2007Hopwood et al., 2008Zhu et al., 2013Li et al., 2014Liu et al., 2016Xia et al., 2016) and six fair quality RCTs (Hu et al., 1993Johansson et al., 1993Wong et al., 1999Pei et al., 2001Min et al., 2008Wang et al., 2014) investigated the effect of acupuncture on functional independence in patients with acute stroke.

The first quality RCT(Gosman-Hedstrom et al., 1998) randomized patients to receive deep electroacupuncture, superficial acupuncture or no acupuncture; all groups received conventional rehabilitation. Functional independence was measured by the Barthel Index (BI) and Sunnaas Index at post-treatment (3 months) and at follow-up (12 months). No significant between-group differences were found on any measure at either time point.

The second high quality RCT(Johansson et al., 2001) randomized patients to receive electroacupuncture, high intensity/low frequency TENS or low intensity (subliminal)/high frequency TENS; all groups received conventional rehabilitation. Functional independence was measured by the BI at follow-up (3 and 12 months post-stroke); measures were not taken at post-treatment (10 weeks). No significant between group differences were found at either follow-up time point.

The third high quality RCT(Sze et al., 2002) randomized patients to receive manual acupuncture or no acupuncture; both groups received conventional rehabilitation. Functional independence was measured by the BI and the Functional Independence Measure (FIM) at post-treatment (10 weeks). No significant between-group differences were found on any measure.

The forth high quality RCT (Park et al., 2005) randomized patients to receive manual acupuncture or sham acupuncture. Functional independence was measured by the BI at post-treatment (2 weeks). No significant between-group differences were found.

The fifth high quality RCT (Hsieh et al., 2007) randomized patients to receive electroacupuncture or no acupuncture; both groups received conventional rehabilitation. Functional independence was measured by the FIM (total, self-care, social, mobility, locomotion, sphincter control, communication) during treatment (2 weeks), at post-treatment (4 weeks), and follow-up (3- and 6-months post-stroke). A significant between-group difference was found on only one score (FIM – social) during treatment (2 weeks), favoring electroacupuncture vs. no acupuncture. There were no other significant between-group differences on any measure, at any time point.

The sixth high quality RCT (Hopwood et al., 2008) randomized patients to receive electroacupuncture or placebo electroacupuncture. Functional independence was measured by the BI during treatment (3 weeks) and at several follow-up time points (6, 12, 25, and 52 weeks); measures were not taken at post-treatment (4 weeks). No significant between-group differences were found at any time point.

The seventh high quality RCT(Zhu et al., 2013) randomized patients to receive acupuncture or no acupuncture; both groups received conventional rehabilitation. Functional independence was measured by the BI at mid-treatment (1 month), post-treatment (3 months) and follow-up (6 months). No significant between-group differences were found at any time point.

The eighth high quality RCT (Li et al., 2014) randomized patients to receive verum acupuncture or sham acupuncture. Functional independence was measured by the modified BI and the modified Rankin Scale (mRS) at baseline, at mid-treatment (2 weeks), post-treatment (4 weeks), and follow-up (12 weeks). Significant between-group differences were found at post-treatment (both measures) and at follow-up (BI only), favoring verum acupuncture vs. sham acupuncture.
Note: Differences at post-treatment reflect change scores from baseline to post-treatment; differences at follow-up reflect scores at that time point as well as change scores from baseline to follow-up.

The ninth high quality RCT (Liu et al., 2016) randomized patients to receive manual acupuncture or no acupuncture. Functional independence was measured by the BI,the mRS and the FIM at post-treatment (2 weeks: FIM) and at follow-up (3 weeks: FIM; 1 month: FIM; 3 months: MRS, BI). No significant between-group differences were found on any measure at any time point.

The tenth high quality RCT (Xia et al., 2016) randomized patients to receive acupuncture or no acupuncture; both groups received standard swallowing training. Functional independence was measured by the modified BI at post-treatment (4 weeks). Significant between group differences were found, favoring acupuncture vs. no acupuncture.

The first fair quality RCT (Hu et al., 1993) randomized patients to receive acupuncture or no acupuncture; both groups received conventional rehabilitation. Functional independence was measured by the BI at post-treatment (4 weeks) and at follow-up (3 months). No significant between-group differences were found at either time point.

The second fair quality RCT (Johansson et al., 1993) randomized patients to receive electroacupuncture or no acupuncture; both groups received conventional rehabilitation. Functional independence was measured by the BI at mid-treatment (1 month post-stroke) and at two follow-up timepoints (3 and 12 months post-stroke); measures were not taken at post-treatment (10 weeks). Significant between-group differences were found at all time points, favoring electroacupuncture vs. no acupuncture.

The third fair quality RCT (Wong et al., 1999) randomized patients to receive electroacupuncture or no acupuncture. Functional independence was measured by the FIM (total, self-care, locomotion, sphincter control, transfers, communication, social interaction) at post-treatment (2 weeks). Significant between-group differences were found (FIM total, self-care, locomotion), favoring electroacupuncture vs. no acupuncture.

The forth fair quality RCT (Pei et al., 2001) randomized patients to receive electroacupuncture or no acupuncture; both groups received conventional rehabilitation. Functional independence was measured by the BI mid-treatment (1 and 2 weeks), at post-treatment (4 weeks) and at follow-up (3 months). Significant between-group differences were found at all time points, favoring electroacupuncture vs. no acupuncture.

The fifth fair quality RCT (Min et al., 2008) randomized patients to receive acupuncture or no acupuncture; both groups received conventional rehabilitation. Functional independence was measured by the modified BI at post-treatment (3 months). Significant between-group differences were found, favoring acupuncture vs. no acupuncture.

The sixth fair quality RCT (Wang et al., 2014) randomized patients to receive electroacupuncture or no electroacupuncture; both groups received conventional rehabilitation. Functional independence was measured by the BI at follow-up (3 and 6 months); measures were not taken at post-treatment (4 weeks). Significant between-group differences were found at 6-month follow-up only, favoring electroacupuncture vs. no electroacupuncture.

Conclusion: There is strong evidence (Level 1a) from eight high quality RCTs and one fair quality RCT that acupuncture is not more effective than comparison interventions (superficial acupuncture, no acupuncture, TENS, conventional rehabilitation, sham or placebo acupuncture) in improving functional independence in patients with acute stroke.
Note:
However, two high quality RCTs and five fair quality RCTs found that acupuncture was more effective than comparison interventions (sham acupuncture, standard swallowing training, no acupuncture, conventional rehabilitation) in improving functional independence in patients with acute stroke.

Health-related quality of life (HRQoL)
Not effective
1a

Five high quality RCTs (Gosman-Hedstrom et al., 1998; Johansson et al., 2001; Park et al., 2005; Hopwood et al., 2008Li et al., 2014) and one fair quality RCT (Johansson et al., 1993) investigated the effect of acupuncture on health-related quality of life (HRQoL) in patients with acute stroke.

The first high quality RCT (Gosman-Hedstrom et al., 1998) randomized patients to receive deep electroacupuncture, superficial acupuncture or no acupuncture; all groups received conventional rehabilitation. HRQoL was measured by the Nottingham Health Profile (NHP – energy level, pain, emotional reaction, sleep, social isolation, physical abilities) at post-treatment (3 months) and at follow-up (12 months). There were no significant between-group differences at post-treatment; there was a significant between-group difference in one component of HRQoL (physical abilities) at follow-up, favoring deep electroacupuncture vs. no acupuncture.

The second high quality RCT (Johansson et al., 2001) randomized patients to receive electroacupuncture, high intensity/low TENS or low intensity (subliminal)/high frequency TENS; all groups received conventional rehabilitation. HRQoL was measured by the NHP at follow-up (3 and 12 months post-stroke); measures were not taken at post-treatment (10 weeks). No significant between group differences were found at both follow-up time points.

The third high quality RCT (Park et al., 2005) randomized patients to receive manual acupuncture or sham acupuncture. HRQoL was measured by the EuroQoL (EuroQoL5 – Visual Analogue Scale) at post-treatment (2 weeks). No significant between-group differences were found.

The forth high quality RCT (Hopwood et al., 2008) randomized patients to receive electroacupuncture or placebo electroacupuncture. HRQoL was measured by the NHP during treatment (3 weeks) and at follow-up (6, 12, 25, and 52 weeks). There was a significant between-group difference in one score (NHP – Energy) during treatment and at all follow-up time points, favoring electroacupuncture vs. placebo acupuncture.

The fifth high quality RCT (Li et al., 2014) randomized patients to receive verum acupuncture or sham acupuncture. HRQoL was measured by the stroke Specialization Quality of Life Scale (SS-QoL) at baseline, at mid-treatment (2 weeks), post-treatment (4 weeks), and at follow-up (12 weeks). Significant between-group differences were found at post-treatment and at follow-up, favoring verum acupuncture vs. sham acupuncture.
Note: Differences at post-treatment reflect change scores from baseline to post-treatment; differences at follow-up reflect scores at that time point as well as change scores from baseline to follow-up.

The fair quality RCT (Johansson et al., 1993) randomized patients to receive electroacupuncture or no acupuncture; both groups received conventional rehabilitation. HRQoL was measured by the modified NHP at follow-up (3, 6 and 12 months post-stroke); measures were not taken at post-treatment (10 weeks). There were significant between-group differences in some components of HRQoL at 3 months post-stroke (energy, mobility, emotion, social isolation), at 6 months post-stroke (energy, mobility, emotion, social isolation, sleep), and at 12 months post-stroke (mobility, emotion), favoring electroacupuncture vs. no acupuncture.

Conclusion: There is strong evidence (Level 1a) from four high quality RCTs that acupuncture is not more effective than comparison interventions (superficial acupuncture, no acupuncture, TENS, sham or placebo acupuncture) in improving health-related quality of life in patients with acute stroke.
Note
: However, one high quality RCT found that acupuncture was more effective than a comparison intervention (sham acupuncture); this study used the SS-QoL to measure quality of life, rather than the NHP used by most other studies. In addition, one fair quality RCT found that acupuncture was more effective than no acupuncture in improving some components of the health-related quality of life.

Instrumental activities of daily living (IADLs)
Not effective
1b

One high quality RCT (Park et al., 2005) investigated the effect of acupuncture on IADLs in patients with acute stroke. This high quality RCT randomized patients to receive manual acupuncture or sham acupuncture. IADLs were measured by the Nottingham Extended ADL scale at post-treatment (2 weeks). No significant between-group differences were found.

Conclusion: There is moderate evidence (Level 1b) from one high quality RCT that acupuncture is not more effective than a comparison intervention (sham acupuncture) in improving IADLs in patients with acute stroke.

Language function
Not effective
1b

One high quality RCT (Rorsman & Johansson, 2006) investigated the effect of acupuncture on language function with acute stroke. This high quality RCT randomized patients to receive acupuncture (including electroacupuncture), high intensity/low frequency TENS or low intensity (subliminal)/high frequency TENS. Language function was measured by the Token Test and FAS Word Fluency Test at follow-up (3 and 12 months post-stroke); measures were not taken at post-treatment (10 weeks). No significant between-group differences were found on any measure at either follow-up time point.

Conclusion: There is moderate evidence (Level 1b) from one high quality RCT that acupuncture is not more effective than comparison interventions (TENS) in improving language function in patients with acute stroke.

Memory
Not effective
1b

One high quality RCT (Rorsman & Johansson, 2006) investigated the effect of acupuncture on memory in patients with acute stroke. This high quality RCT randomized patients to receive acupuncture (including electroacupuncture), high intensity/low frequency TENS or low intensity (subliminal)/high frequency TENS. Memory was measured by the Rey Auditory Verbal Learning Test and Facial Recognition Memory Test at follow-up (3 and 12 months post-stroke); measures were not taken at post-treatment (10 weeks). No significant between-group differences were found on either measure of memory at either time point.

Conclusion: There is moderate evidence (Level 1b) from one high quality RCT that acupuncture is not more effective than comparison interventions (TENS) in improving memory in patients with acute stroke.

Mobility
Not effective
1b

One high quality RCT (Johansson et al., 2001) and one fair quality RCT (Johansson et al., 1993) investigated the effect of acupuncture on mobility in patients with acute stroke.

The high quality RCT (Johansson et al., 2001) randomized patients to receive electroacupuncture, high intensity/low TENS or low intensity (subliminal)/high frequency TENS; all groups received conventional rehabilitation. Mobility was measured by the Rivermead Mobility Index at follow-up (3 and 12 months post-stroke); measures were not taken at post-treatment (10 weeks). No significant between-group differences were found at either follow-up time point.

The fair quality RCT (Johansson et al., 1993) randomized patients to receive electroacupuncture or no acupuncture; both groups received conventional rehabilitation. Mobility was measured by the modified Chart for Motor Capacity Assessment (Walking) at mid-treatment (1 month post-stroke) and at follow-up (3 months post-stroke); measures were not taken at post-treatment (10 weeks). Significant between-group differences were found at both time points, favoring electroacupuncture vs. no acupuncture.

Conclusion: There is moderate evidence (Level 1b) from one high quality RCT that electroacupuncture is not more effective than comparison interventions (TENS) in improving mobility in patients with acute stroke.
Note: 
However, one RCT found that acupuncture was more effective than no acupuncture in improving mobility in patients with acute stroke.

Motor function
Conflicting
4

Five high quality RCTs (Sze et al., 2002Hsieh et al., 2007Tan et al., 2013Li et al., 2014Liu et al., 2016) and three fair quality RCTs (Johansson et al., 1993Pei et al., 2001Min et al., 2008) investigated the effect of acupuncture on motor function in patients with acute stroke.

The first high quality RCT (Sze et al., 2002) randomized patients to receive manual acupuncture or no acupuncture; both groups received conventional rehabilitation. Motor function measured by the Fugl-Meyer Assessment (FMA) at post-treatment (10 weeks). No significant between-group differences were found.

The second high quality RCT (Hsieh et al., 2007) randomized patients to receive electroacupuncture or no acupuncture; both groups received conventional rehabilitation. Motor function was measured by the FMA (total score) at mid-treatment (2 weeks), post-treatment (4 weeks), and follow-up (3 and 6 months post-stroke). Significant between-group differences were found at mid-treatment, post-treatment and at 3 months post-stroke, favoring electroacupuncture vs. no acupuncture.

The third high quality RCT (Tan et al., 2013) randomized patients to receive electroacupuncture or no electroacupuncture. Motor function was measured by the FMA at post-treatment (14 days). Significant between-group differences were found at post-treatment, favoring electroacupuncture vs. no electroacupuncture.

The fourth high quality RCT (Li et al., 2014) randomized patients to receive verum acupuncture or sham acupuncture. Motor function was measured by the FMA – Upper and Lower Extremity scores combined at baseline, at mid-treatment (2 weeks), at post-treatment (4 weeks), and at follow-up (12 weeks). Significant between-group differences were found at post-treatment and at follow-up, favoring verum acupuncture vs. sham acupuncture.
Note: Differences at post-treatment reflect change scores from baseline to post-treatment; differences at follow-up reflect scores at that time point as well as change scores from baseline to follow-up.

The fifth high quality RCT (Liu et al., 2016) randomized patients to receive manual acupuncture or no acupuncture. Motor function was measured by the FMA at follow-up (1 month); measures were not taken at post-treatment (2 weeks). No significant between-group differences were found.

The first fair quality RCT (Johansson et al., 1993) randomized patients to receive electroacupuncture or no acupuncture; both groups received conventional rehabilitation. Motor function was measured by the modified Chart for Motor Capacity Assessment (motor function) at 1 and 3 months post-stroke (follow-up); measures were not taken at post-treatment (10 weeks). No significant between group differences were found at either time point.

The second fair quality RCT (Pei et al., 2001) randomized patients to receive electroacupuncture or no acupuncture; both groups received conventional rehabilitation. Motor function was measured by the FMA at mid-treatment (1 and 2 weeks), post-treatment (4 weeks) and at follow-up (3 months). Significant between-group differences were found at all time points, favoring electroacupuncture vs. no acupuncture.

The third fair quality RCT (Min et al., 2008) randomized patients to receive acupuncture or no acupuncture; both groups received conventional rehabilitation. Motor function was measured by the FMA at post-treatment (3 months). A significant between-group difference was found at post-treatment, favoring acupuncture vs. no acupuncture.

Conclusion: There is conflicting evidence (Level 4) regarding the effect of acupuncture on motor function. Two high quality RCTs and one fair quality RCT reported that acupuncture is not more effective than no acupuncture, whereas two other high quality RCTs and two fairquality RCTs found that acupuncture was more effective than comparison interventions (no/sham acupuncture) in improving motor function in patients with acute stroke. A fifth high quality RCT also reported of significant differences in change scores at post-treatment and follow-up.
Note:
There was significant variation between studies in type, frequency and duration of acupuncture.

Motor function (lower extremity)
Not effective
1a

Three high quality RCTs (Hsieh et al., 2007Zhu et al., 2013Chen et al., 2016) and two fair quality RCTs (Wong et al., 1999Min et al., 2008) investigated the effect of acupuncture on lower extremity motor function in patients with acute stroke.

The first quality RCT (Hsieh et al., 2007) randomized patients to receive electroacupuncture or no acupuncture; both groups received conventional rehabilitation. Lower extremity motor function was measured by the Fugl Meyer Assessment (FMA – hip/knee/ankle motor function, lower extremity coordination and speed) at mid-treatment (2 weeks), post-treatment (4 weeks), and follow-up (3 and 6 months post-stroke). No significant between-group differences were found at any time point.

The second high quality RCT (Zhu et al., 2013) randomized patients to receive acupuncture or no acupuncture; both groups received conventional rehabilitation. Lower extremity motor function was measured by the Fugl-Meyer Assessment – Lower Extremity (FMA-LE) at mid-treatment (1 month), post-treatment (3 months), and at follow-up (6 months). No significant between-group differences were found at any time point.

The third high quality RCT (Chen et al., 2016) randomized patients to receive electroacupuncture or no acupuncture; both groups received conventional rehabilitation. Lower extremity motor function was measured by the FMA-LE at baseline, at post-treatment (3 weeks) and at follow-up (7 weeks). There were no significant differences at post-treatment; there were significant differences in change scores from baseline to follow-up, favoring acupuncture vs. no acupuncture.

The first fair quality RCT (Wong et al., 1999) randomized patients to receive electroacupuncture or no acupuncture. Lower extremity motor function was measured using Brunnstrom’s lower limb motor recovery at post-treatment (2 weeks). Significant between-group differences were found, favoring electroacupuncture vs. no acupuncture.

The second fair quality RCT (Min et al., 2008) randomized patients to receive acupuncture or no acupuncture; both groups received conventional rehabilitation. Lower extremity motor function was measured by the FMA–LE at post-treatment (3 months). Significant between-group difference were found, favoring acupuncture vs. no acupuncture.

Conclusion: There is strong evidence (level 1a) from 3 high quality RCTs that acupuncture is not more effective than a comparison intervention (no acupuncture) for improving lower extremity motor function in patients with acute stroke.
Note: 
One of the high quality RCTs reported a significant difference in change scores at follow-up, in favour of acupuncture vs. no acupuncture. Further, two fair quality RCTs reported that acupuncture was more effective than no acupuncture. There was significant variation in the frequency and duration of interventions.

Motor function (upper extremity)
Not effective
1a

Three high quality RCTs (Hsieh et al., 2007Zhu et al., 2013Chen et al., 2016) and two fair quality RCTs (Wong et al., 1999Min et al., 2008) investigated the effect of acupuncture on upper extremity motor function in patients with acute stroke.

The first high quality RCT (Hsieh et al., 2007) randomized patients to receive electroacupuncture or no acupuncture; both groups received conventional rehabilitation. Upper extremity motor function was measured by the Fugl Meyer Assessment (FMA – shoulder / elbow / wrist / hand motor function, upper extremity coordination and speed) during treatment (2 weeks), at post-treatment (4 weeks), and follow-up (3 and 6 months post-stroke). Significant between-group differences were found during treatment (FMA – hand motor function, upper extremity coordination and speed), post-treatment (FMA – wrist motor function, hand motor function, upper extremity coordination and speed), and at both follow-up time points (FMA – wrist motor function, hand motor function, upper extremity coordination and speed), favoring electroacupuncture vs. no acupuncture.

The second high quality RCT (Zhu et al., 2013) randomized patients to receive acupuncture or no acupuncture; both groups received conventional rehabilitation. Upper extremity motor function was measured by the Fugl-Meyer Assessment – Upper Extremity scale (FMA-UE) at mid-treatment (1 month), post-treatment (3 months) and follow-up (6 months). No significant between-group differences were found at any time point.

The third high quality RCT (Chen et al., 2016) randomized patients to receive electroacupuncture or no acupuncture; both groups received conventional rehabilitation. Upper extremity motor function was measured by the FMA-UE at post-treatment (3 weeks) and follow-up (7 weeks). No significant between-group differences were found at either time point.

The first fair quality RCT (Wong et al., 1999) randomized patients to receive electroacupuncture or no acupuncture. Upper extremity motor function was measured by Brunnstrom’s upper limb motor recovery at post-treatment (2 weeks). Significant between-group differences were found, favoring electroacupuncture vs. no acupuncture.

The second fair quality RCT (Min et al., 2008) randomized patients to receive acupuncture or no acupuncture; both groups received conventional rehabilitation. Upper extremity motor function was measured by the FMA-UE at post-treatment (3 months). A significant between-group difference was found, favoring acupuncture vs. no acupuncture.

Conclusion: There is strong evidence (Level 1a) from two high quality RCTs that acupuncture is not more effective than a comparison intervention (no acupuncture) in improving upper extremity motor function in patients with acute stroke.
Note: 
However; one high quality RCT and two fair quality RCTs found that acupuncture was more effective than a comparison intervention (no acupuncture) in improving upper extremity motor function in patients with acute stroke. Studies varied in terms of the intervention, frequency (2-6 times/week) and duration (2 weeks – 3 months) of the intervention, and outcome measures used.

Range of motion
No effective
1b

One high quality RCT (Hsieh et al., 2007) investigated the effect of acupuncture on range of motion in patients with acute stroke. This high quality RCT randomized patients to receive electroacupuncture or no acupuncture; both groups received conventional rehabilitation. Range of motion was measured by the Fugl Meyer Assessment (FMA – range of motion) at mid-treatment (2 weeks), post-treatment (4 weeks), and follow-up (3 and 6 months post-stroke). There was a significant between-group difference in range of motion at 3 months post-stroke only, favoring electroacupuncture vs. no acupuncture.

Conclusion: There is moderate evidence (Level 1b) from one high quality RCT that electroacupuncture is not more effective than a comparison intervention (no acupuncture) in improving range of motion in patients with acute stroke.

Sensation
Not effective
1b

One high quality RCT (Hsieh et al., 2007) investigated the effects of acupuncture on sensation in patients with acute stroke. The high quality RCT randomized patients to receive electroacupuncture or no acupuncture; both groups received conventional rehabilitation. Sensation was measured by the Fugl Meyer Assessment (FMA – sensation) at mid-treatment (2 weeks), post-treatment (4 weeks), and follow-up (3 and 6 months post-stroke). No significant between-group differences were found at any time point.

Conclusion: There is moderate evidence (Level 1b) from one high quality RCT that acupuncture is not more effective than a comparison intervention (no acupuncture) in improving sensation in patients with acute stroke.

Spasticity
Conflicting
4

Two high quality RCTs (Park et al., 2005; Li et al., 2014) investigated the effect of acupuncture on spasticity in patients with acute stroke.

The first high quality RCT (Park et al., 2005) randomized patients to receive manual acupuncture or sham acupuncture. spasticity was measured by the Modified Ashworth Scale (MAS) at post-treatment (2 weeks). No significant between-group differences were found.

The second high quality RCT (Li et al., 2014) randomized patients to receive verum acupuncture or sham acupuncture. spasticity was measured by the MAS at baseline, at mid-treatment (2 weeks), post-treatment (4 weeks), and follow-up (12 weeks). Significant between-group differences in spasticity were found at post-treatment and follow-up, favoring verum acupuncture vs. sham acupuncture.
Note: Differences at post-treatment reflect change scores from baseline to post-treatment; differences at follow-up reflect scores at that time point as well as change scores from baseline to follow-up.

Conclusion: There is conflicting evidence (Level 4) regarding the effect of acupuncture on spasticity in patients with acute stroke. While one high quality RCT found manual acupuncture (2 weeks duration) was not more effective than sham acupuncture, a second high quality RCT reported a significant difference in change scores following verum acupuncture (4 weeks duration), in improving spasticity in patients with acute stroke.

Strength
Not effective
1a

Two high quality RCTs (Park et al., 2005; Hopwood et al., 2008) investigated the effect of acupuncture on strength in patients with acute stroke.

The first high quality RCT (Park et al., 2005) randomized patients to receive manual acupuncture or sham acupuncture. Strength was measured by the Motricity Index (MI) at post-treatment (2 weeks). No significant between-group differences were found.

The second quality RCT (Hopwood et al., 2008) randomized patients to receive electroacupuncture or placebo electroacupuncture. Strength was measured by the MI at mid-treatment (3 weeks) and at follow-up (6, 12, 25, and 52 weeks); measures were not taken at post-treatment (4 weeks). No significant between-group differences were found at any time point.

Conclusion: There is strong evidence (Level 1a) from two high quality RCTs that acupuncture is not more effective than comparison interventions (sham acupuncture, placebo electroacupuncture) in improving strength in patients with acute stroke.

Stroke outcomes
Not effective
1a

Seven high quality RCTs (Gosman-Hedstrom et al., 1998; Park et al., 2005; Tan et al., 2013; Li et al., 2014; Zhang et al., 2015; Chen et al., 2016, Liu et al., 2016) and three fair quality RCTs (Si et al., 1998; Pei et al., 2001; Wang et al., 2014) investigated the effect of acupuncture on stroke outcomes in patients with acute stroke.

The first high quality RCT (Gosman-Hedstrom et al., 1998) randomized patients to receive deep electroacupuncture, superficial acupuncture or no acupuncture; all groups received conventional rehabilitation. stroke outcomes were measured by the Scandinavian stroke Study Group – Neurological score at post-treatment (3 months) and follow-up (12 months). No significant between-group differences were found at either time point.

The second high quality RCT (Park et al., 2005) randomized patients to receive manual acupuncture or sham acupuncture. stroke outcomes were measured by the National Institutes of Health stroke Scale (NIHSS) at post-treatment (2 weeks). No significant between-group differences were found.

The third high quality RCT (Tan et al., 2013) randomized patients to receive electroacupuncture or no electroacupuncture. stroke outcomes were measured by the Modified Edinburg Scandinavian stroke Scale and the NIHSS at post-treatment (14 days). Significant between-group differences were found on both measures at post-treatment, favoring electroacupuncture vs. no electroacupuncture.

The forth high quality RCT (Li et al., 2014) randomized patients to receive verum acupuncture or sham acupuncture. stroke outcomes were measured by the NIHSS at mid-treatment (2 weeks), post-treatment (4 weeks), and follow-up (12 weeks). No significant between-group differences were found at any time point.

The fifth high quality RCT (Zhang et al., 2015) randomized patients to receive acupuncture or no acupuncture. stroke outcomes were measured by the Scandinavian stroke Scale at post-treatment (3 weeks). Significant between-group differences were found, favoring acupuncture vs. no acupuncture.
Note: Results were significant only for participants who had received 10 or more acupuncture sessions.

The sixth high quality RCT (Chen et al., 2016) randomized patients to receive electroacupuncture or no acupuncture; both groups received conventional rehabilitation. stroke outcomes were measured by the NIHSS at baseline, during treatment (1 week), at post-treatment (3 weeks), and follow-up (7 weeks). There were no significant differences between groups during treatment or at post-treatment. There was a significant between-group difference in change scores from baseline to follow-up, favoring acupuncture vs. no acupuncture.

The seventh high quality RCT (Liu et al., 2016) randomized patients to receive manual acupuncture or no acupuncture. stroke outcomes were measured by the NIHSS at post-treatment (2 weeks) and follow-up (3, 4, 12 weeks). No significant between-group differences were found at any time point.

The first fair quality RCT (Si et al., 1998) randomized patients to receive electroacupuncture or no acupuncture. stroke outcomes were measured by the Chinese stroke Scale (CSS – total score, motor shoulder/hand/leg, level of consciousness, extraocular movements, facial palsy, speech, walking capacity) at discharge from hospital (average of 37±12 days). Significant between group differences in some stroke outcomes (CSS – total, motor shoulder/hand/leg) were found at discharge, favoring electroacupuncture vs. no acupuncture.

The second fair quality RCT (Pei et al., 2001) randomized patients to receive electroacupuncture or no acupuncture; both groups received conventional rehabilitation. stroke outcomes were measured by the CSS during treatment (1 and 2 weeks), at post-treatment (4 weeks) and at follow-up (3 months). Significant between-group differences in stroke outcomes were found at 2 weeks, 4 weeks and 3 months, favoring electroacupuncture vs. no acupuncture.

The third fair quality RCT (Wang et al., 2014) randomized patients to receive electroacupuncture or no acupuncture; both groups received conventional rehabilitation. stroke outcomes were measured by the NIHSS at post-treatment (4 weeks) and at follow-up (3 months). Significant between-group differences were found at post-treatment, favoring electroacupuncture vs. no electroacupuncture. These differences were not maintained at follow-up.

Conclusion: There is strong evidence (Level 1a) from five high quality RCTs that acupuncture is not more effective than comparison interventions (superficial/no/sham acupuncture) in improving stroke outcomes in patients with acute stroke.
Note:
However, two high quality RCTs and three fair quality RCTs found that acupuncture is more effective than a comparison intervention (no acupuncture) in improving stroke outcomes in patients with acute stroke. Differences between studies, including variation in the type of acupuncture, treatment frequency/duration and outcome measures used may account for this discrepancy in findings.

Swallowing function
Effective
1a

Three high quality RCTs (Park et al., 2005; Chen et al., 2016; Xia et al., 2016) investigated the effect of acupuncture on swallowing function in patients with acute stroke.

The first high quality RCT (Park et al., 2005) randomized patients to receive manual acupuncture or sham acupuncture. Swallowing function was measured by the Bedside Swallowing Assessment (BSA) at post-treatment (2 weeks). Significant between group differences were found, favoring sham acupuncture vs. manual acupuncture (i.e. participants who received manual acupuncture presented with a higher incidence of unsafe swallow than participants who received sham acupuncture).

The second high quality RCT (Chen et al., 2016) randomized patients to receive electroacupuncture or no acupuncture; both groups received conventional rehabilitation. Swallowing function was measured by the BSA at post-treatment (3 weeks) and follow-up (7 weeks), and by Videofluoroscopic Swallowing Study (VFSS) at follow-up (7 weeks). Significant between-group differences were found at post-treatment (BSA) and at follow-up (BSA, VFDSS), favoring acupuncture vs. no acupuncture.

The third high quality RCT (Xia et al., 2016) randomized patients to receive acupuncture or no acupuncture; both groups received standard swallowing training. Swallowing function was measured by the Standardized Swallowing Assessment at post-treatment (4 weeks). Significant between-group differences were found, favoring acupuncture vs. no acupuncture.

Conclusion: There is strong evidence (Level 1a) from two high quality RCTs that acupuncture is more effective than a comparison intervention (no acupuncture) in improving swallowing function in patients with acute stroke.
Note:
However, one high quality RCT found that acupuncture was LESS effective than a comparison intervention (sham acupuncture) in improving swallowing function in patients with acute stroke.

Swallowing-related quality of life
Effective
1b

One high quality RCT (Xia et al., 2016) investigated the effects of acupuncture on swallowing-related quality of life in patients with acute stroke and subsequent dysphagia. This high quality RCT randomized patients to receive acupuncture or no acupuncture; both groups received standard swallowing training. Swallowing-related quality of life was measured with the Swallowing Related Quality of Life scale at post-treatment (4 weeks). Significant between-group differences were found, favoring acupuncture vs. no acupuncture.

Conclusion: There is moderate evidence (Level 1b) from one high quality RCT that acupuncture is more effective than a comparison intervention (no acupuncture with standard swallowing training) in improving swallowing related quality of life in patients with acute stroke and subsequent dysphagia.

Unilateral spatial neglect
Not effective
1b

One high quality RCT (Rorsman & Johansson, 2006) investigated the effect of acupuncture on unilateral spatial neglect in patients with acute stroke. This high quality RCT randomized patients to receive acupuncture (including electroacupuncture), high intensity/low frequency TENS or low intensity (subliminal)/high frequency TENS. Unilateral spatial neglect was measured by the Star Cancellation Test and Time Perception Test at follow-up (3 and 12 months post-stroke); measures were not taken at post-treatment (10 weeks). No significant between-group differences were found on any measure at either time point.

Conclusion: There is moderate evidence (Level 1b) from one high quality RCT that acupuncture is not more effective than comparison interventions (TENS) in improving unilateral spatial neglect in patients with acute stroke.

Walking speed
Not effective
1b

One high quality RCT (Park et al., 2005) investigated the effect of acupuncture on walking speed in patients with acute stroke. This high quality RCT randomized patients to receive manual acupuncture or sham acupuncture. Walking speed was measured by the 10 Meter Walk Test at post-treatment (2 weeks). No significant between-group differences were found.

Conclusion: There is moderate evidence (Level 1b) from one high quality RCT that acupuncture is not more effective than a comparison intervention (sham acupuncture) in improving walking speed in patients with acute stroke.

Subacute phase

Range of motion
Not effective
1b

One high quality RCT (Naeser et al., 1992) investigated the effect of acupuncture on range of motion in patients with subacute stroke. This high quality RCT randomized patients to receive electroacupuncture or sham acupuncture. Isolated active range of motion was measured at post-treatment (4 weeks). No significant between-group differences were found.
Note: A subgroup analysis of patients with the lesion in half or less than half of the motor pathway areas revealed significant between-group differences, favoring electroacupuncture vs. sham acupuncture.

Conclusion: There is moderate evidence (Level 1b) from one high quality RCT that electroacupuncture is not more effective than a comparison intervention (sham acupuncture) in improving isolated active range of motion in patients with subacute stroke.

Chronic phase

Depression
Not effective
1a

Two high quality RCTs (Fink et al., 2004; Wayne et al., 2005) investigated the effect of acupuncture on depression in patients with chronic stroke. This first high quality RCT (Fink et al., 2004) randomized patients to receive acupuncture or placebo acupuncture. depression was measured by the von Zerssen depression Scale at post-treatment (4 weeks) and follow-up (3 months). No significant between-group differences were found at either time point. 

The second high quality RCT (Wayne et al., 2005) randomized patients to receive acupuncture or sham acupuncture. depression was measured by the Center for Epidemiological Surveys depression at post-treatment (12 weeks). No significant between-group differences were found.

Conclusion: There is strong evidence (Level 1a) from two high quality RCTs that acupuncture is not more effective than a comparison intervention (placebo/sham acupuncture) in improving depression in patients with chronic stroke.

Functional independence
Not effective
1b

One high quality RCT (Wayne et al, 2005) investigated the effect of acupuncture on functional independence in patients with chronic stroke. This high quality RCT randomized patients to receive acupuncture or sham acupuncture. Functional independence was measured by the Barthel Index at post-treatment (12 weeks). No significant between-group differences were found.

Conclusion: There is moderate evidence (Level 1b) from one high quality RCT that acupuncture is not more effective than a comparison intervention (sham acupuncture) in improving functional independence in patients with chronic stroke.

Gait parameters
Not effective
1b

One high quality RCT (Fink et al., 2004) investigated the effect of acupuncture on gait parameters in patients with chronic stroke. This high quality RCT randomized patients to receive acupuncture or placebo acupuncture. gait parameters (step length, cadence, mode of initial foot contact) were measured at first treatment, post-treatment (4 weeks), and follow-up (3 months). No significant between-group differences were found at any time point.

Conclusion: There is moderate evidence (Level 1b) from one high quality RCT that acupuncture is not more effective than a comparison intervention (placebo acupuncture) in improving gait parameters in patients with chronic stroke.

Grip strength
Not effective
1b

One high quality RCT (Wayne et al, 2005) investigated the effect of acupuncture on grip strength in patients with chronic stroke. This high quality RCT randomized patients to receive acupuncture or sham acupuncture. Grip strength was measured by Jamar dynamometer at post-treatment (12 weeks). No significant between-group differences were found.

Conclusion: There is moderate evidence (Level 1b) from one high quality RCT that acupuncture is not more effective than a comparison intervention (sham acupuncture) in improving grip strength in patients with chronic stroke.

Health-related quality of life (HRQoL)
Not effective
1a

Two high quality RCTs (Fink et al., 2004; Wayne et al., 2005) investigated the effect of acupuncture on HRQoL in patients with chronic stroke.

This first high quality RCT (Fink et al., 2004) randomized patients to receive acupuncture or placebo acupuncture. HRQoL was measured by the Nottingham Health Profile and the Everyday Life Questionnaire at post-treatment (4 weeks) and follow-up (3 months). No significant between-group differences were found on either measure at either time point. 

The second high quality RCT (Wayne et al, 2005) randomized patients to receive acupuncture or sham acupuncture. HRQoL was measured by the Nottingham Health Profile at post-treatment (12 weeks). No significant between-group differences were found.

Conclusion: There is strong evidence (Level 1a) from two high quality RCTs that acupuncture is not more effective than a comparison intervention (placebo/sham acupuncture) in improving health-related quality of life in patients with chronic stroke.

Impression of improvement
Not effective
1b

One high quality RCT (Fink et al., 2004) investigated the effect of acupuncture on impression of improvement in patients with chronic stroke. This high quality RCT randomized patients to receive acupuncture or placebo acupuncture. Impression of improvement was measured by the Clinical Global Impressions Scale at first treatment, post-treatment (4 weeks), and follow-up (3 months). Significant between-group differences in patients’ impression of improvement were found at post-treatment, favoring placebo acupuncture vs. acupuncture.

Conclusion: There is moderate evidence (Level 1b) from one high quality RCT that acupuncture is not more effective than a comparison intervention (placebo acupuncture) in increasing the impression of improvement in patients with chronic stroke. In fact, patients who received acupuncture showed lower impression of improvement as compared to those who received placebo acupuncture.

Mobility
Not effective
1b

One high quality RCT (Fink et al., 2004) investigated the effect of acupuncture on mobility in patients with chronic stroke. This high quality RCT randomized patients to receive acupuncture or placebo acupuncture. Mobility was measured by the Rivermead Mobility Index at first treatment, post-treatment (4 weeks), and follow-up (3 months). No significant between-group differences were found at any time point.

Conclusion: There is moderate evidence (Level 1b) from one high quality RCT that acupuncture is not more effective than a comparison intervention (placebo acupuncture) in improving mobility in patients with chronic stroke.

Motor function
Not effective
1a

Two high quality RCTs (Fink et al., 2004, Wayne et al., 2005) investigated the effect of acupuncture on motor function in patients with chronic stroke.

This first high quality RCT (Fink et al., 2004) randomized patients to receive acupuncture or placebo acupuncture. Motor function was measured by the Rivermead Motor Assessment at first treatment, post-treatment (4 weeks), and follow-up (3 months). No significant between-group differences were found at any time point.

The second high quality RCT (Wayne et al., 2005) randomized patients to receive acupuncture or sham acupuncture. Motor function was measured by the Fugl-Meyer Assessment at post-treatment (12 weeks). No significant between-group differences were found.

Conclusion: There is strong evidence (Level 1a) from two high quality RCTs that acupuncture is not more effective than a comparison intervention (placebo/sham acupuncture) in improving motor function in patients with chronic stroke.

Pain
Not effective
1b

One high quality RCT (Fink et al., 2004) investigated the effect of acupuncture on pain in patients with chronic stroke. This high quality RCT randomized patients to receive acupuncture or placebo acupuncture. Pain was measured by Visual Analogue Scale at first treatment, post-treatment (4 weeks), and follow-up (3 months). No significant between-group differences were found at any time point.

Conclusion: There is moderate evidence (Level 1b) from one high quality RCT that acupuncture is not more effective than a comparison intervention (placebo acupuncture) in improving pain in patients with chronic stroke.

Range of motion (upper extremity)
Not effective
1a

Two high quality RCTs (Wayne et al., 2005, Schaechter et al., 2007) investigated the effect of acupuncture on upper extremity range of motion in patients with chronic stroke.

The first high quality RCT (Wayne et al., 2005) randomized patients to receive acupuncture or sham acupuncture. Upper extremity range of motion (shoulder, elbow, forearm, wrist, thumb, digits) was measured at post-treatment (12 weeks). No significant between-group differences were found.

The second high quality RCT (Schaechter et al., 2007) randomized patients to receive acupuncture with electroacupuncture or sham acupuncture with sham electroacupuncture. Upper extremity active assisted range of motion was measured at 2 weeks post-treatment (12 weeks). No significant between-group differences were found.

Conclusion: There is strong evidence (Level 1a) from two high quality RCTs that acupuncture is not more effective than comparison interventions (sham acupuncture, sham electroacupuncture) in improving upper extremity range of motion in patients with chronic stroke.

Spasticity (lower extermity)
Not effective
1b

One high quality RCT (Fink et al., 2004) investigated the effect of acupuncture on lower extremity spasticity in patients with chronic stroke. This high quality RCT randomized patients to receive acupuncture or placebo acupuncture. Ankle spasticity was measured by the Modified Ashworth Scale and the Hoffman’s reflex (Hmax/Mmax ratio of the spastic leg) using the Nicolet Viking II device at first treatment, post-treatment (4 weeks), and follow-up (3 months). Significant between-group differences in spasticity (Hoffman’s reflex) were found at post-treatment, favoring placebo acupuncture vs. acupuncture. These differences were not maintained at follow-up.

Conclusion: There is moderate evidence (Level 1b) from one high quality RCT that acupuncture is not more effective than a comparison intervention (placebo acupuncture) in reducing ankle spasticity in patients with chronic stroke. In fact, patients who received acupuncture showed greater spasticity in their affected ankle as compared to those who received placebo acupuncture.

Spasticity (upper extermity)
Not effective
1a

Two high quality RCTs (Wayne et al., 2005; Schaechter et al., 2007) and one poor quality crossover RCT (Mukherjee et al., 2007) investigated the effect of acupuncture on upper extremity spasticity in patients with chronic stroke.

The first high quality RCT (Wayne et al., 2005) randomized patients to receive acupuncture or sham acupuncture. spasticity in the elbow and wrist was measured by the Modified Ashworth Scale at post-treatment (12 weeks). No significant between-group differences were found.

The second high quality RCT (Schaechter et al., 2007) randomized patients to receive acupuncture with electroacupuncture or sham acupuncture with sham electroacupuncture. Upper extremity spasticity was measured by the Modified Ashworth Scale at 2 weeks post-treatment (12 weeks). No significant between-group differences were found.

The poor quality crossover RCT (Mukherjee et al., 2007) randomized patients to receive electroacupuncture or no electroacupuncture; both groups received strengthening exercises. spasticity of the wrist was measured at post-treatment (6 weeks). Significant between-group differences on one measure of wrist spasticity were found, favoring electroacupuncture vs. no electroacupuncture.
Note: Other measures of spasticity were taken, however between-group analyses were not performed.

Conclusion: There is strong evidence (Level 1a) from two high quality RCTs that acupuncture is not more effective than comparison interventions (sham acupuncture, sham electroacupuncture) in reducing upper extremity spasticity in patients with chronic stroke.
Note
: However, a poor quality crossover RCT found a significant difference on one measure of wrist spasticity, in favour of electroacupuncture + strengthening exercises alone vs. strengthening exercises alone.

Walking endurance
Not effective
1b

One high quality RCT (Fink et al., 2004) investigated the effect of acupuncture on walking endurance in patients with chronic stroke. This high quality RCT randomized patients to receive acupuncture or placebo acupuncture. Walking endurance was measured by the 2-Minute Walk Test at first treatment, post-treatment (4 weeks), and follow-up (3 months). No significant between-group differences were found at any time point.

Conclusion: There is moderate evidence (Level 1b) from one high quality RCT that acupuncture is not more effective than a comparison intervention (placebo acupuncture) in improving walking endurance in patients with chronic stroke.

Phase not specific to one period

Balance
Not effective
1b

One high quality RCT (Alexander et al., 2004) investigated the effect of acupuncture on balance in patients with stroke. This high quality RCT randomized patients with acute/subacute stroke to receive acupuncture or no acupuncture for 2 weeks; both groups received conventional rehabilitation. Balance was measured by the Fugl-Meyer Assessment (FMA – Balance) at discharge from hospital. No significant between-group differences were found.

Conclusion: There is moderate evidence (Level 1b) from one high quality RCT that acupuncture is not more effective than a comparison intervention (no acupuncture) in improving balance in patients with stroke.

Cognitive function
Effective
1b

One high quality RCT (Jiang et al., 2016) investigated the effect of acupuncture on cognitive function in patients with stroke. This high quality RCT randomized patients with acute/subacute stroke to receive acupuncture (AC) + conventional rehabilitation (CR), computerized cognitive rehabilitation (COG) + CR, combined AC+COG+CR, or CR alone. Cognitive function was measured by the Mini Mental State Examination and the Montreal Cognitive Assessment (MOCA) at baseline and at post-treatment (12 weeks). Significant between-group differences in change scores from baseline to post-treatment were found on both measures, favoring AC+CR vs. CR alone. There were no significant between-group differences between AC+CR vs. COG+CR.
Note: Significant between-group differences in change scores of both measures were also found in favour of COG+CR vs. CR alone; AC+COG+CR vs. CR alone; AC+COG+CR vs. AC+CR; and AC+COG+CR vs. COG+CR.

Conclusion: There is moderate evidence (Level 1b) from one high quality RCT that acupuncture is more effective than a comparison intervention (conventional rehabilitation) in improving cognitive function in patients with stroke.
Note:
Combined acupuncture + computerized cognitive training was also found to be more effective than comparison interventions (acupuncture alone, computerized cognitive training alone, conventional rehabilitation) in improving cognitive function in patients with stroke.

Functional independence
Not effective
1a

Five high quality RCTs (Sallstrom et al., 1996 – and a follow-up by Kjendahl et al., 1997 –; Alexander et al., 2004; Schuler et al., 2005; Zhuang et al., 2012; Jiang et al., 2016) and one fair quality RCTs (Hegyi & Szigeti, 2012) investigated the effect of acupuncture on functional independence in patients with stroke.

The first high quality RCT (Sallstrom et al., 1996) randomized patients with acute/subacute stroke to receive electroacupuncture or no acupuncture; both groups received conventional rehabilitation. Functional independence was measured by the Sunnaas Index at post-treatment (6 weeks) and at 1 year post-discharge from hospital (Kjendahl et al., 1997, follow-up study). Significant between-group differences were found at post-treatment and at follow-up, favoring electroacupuncture vs. no acupuncture.

The second high quality RCT (Alexander et al., 2004) randomized patients with acute/subacute stroke to receive acupuncture or no acupuncture for 2 weeks; both groups received conventional rehabilitation. Functional independence was measured by the Functional Independence Measure (FIM) at discharge from hospital. A significant between-group difference was found in only one measure of functional independence (tub/shower transfer), favoring acupuncture vs. no acupuncture.

The third high quality RCT (Schuler et al., 2005) randomized patients with acute/subacute stroke to receive electroacupuncture or placebo acupuncture. Functional independence was measured by the Barthel Index at post-treatment (4 weeks) and at follow-up (6 months). No significant between-group differences were found at either time point.

The forth high quality RCT (Zhuang et al., 2012) randomized patients with acute/subacute stroke to receive acupuncture, conventional rehabilitation or combined acupuncture with conventional rehabilitation. Functional independence was measured by the modified Barthel Index at mid-treatment (2 weeks) and at post-treatment (4 weeks). No significant between-group differences were found at either time point.

The fifth high quality RCT (Jiang et al., 2016) randomized patients with acute/subacute stroke to receive acupuncture (AC) + conventional rehabilitation (CR), computerized cognitive rehabilitation (COG) + CR, combined AC+COG+CR, or CR alone. Functional independence was measured at baseline and at post-treatment (12 weeks) by the FIM. Significant between-group differences were found in FIM change scores from baseline to post-treatment, favoring AC+CR vs. CR alone. There were no significant differences between AC+CR vs. COG+CR.
Note: Significant differences in FIM change scores were also found in favour of COG+CR vs. CR alone; AC+COG+CR vs. CR alone; AC+COG+CR vs. AC+CR; and AC+COG+CR vs. COG+CR.

The fair quality RCT (Hegyi & Szigeti, 2012) randomized patients with acute/subacute stroke to receive acupuncture or no acupuncture for the time of hospitalization (duration not specified); both groups received conventional physical therapy. Functional independence was measured by the Barthel Index at 2 years post-stroke. Significant between-group differences were found, favoring acupuncture vs. no acupuncture.

Conclusion: There is strong evidence (Level 1a) from three high quality RCTs that acupuncture is not more effective than comparison interventions (no/placebo acupuncture, conventional rehabilitation) in improving functional independence in patients with stroke.
Note:
However, two high quality RCTs and one fair quality RCT found that acupuncture was more effective than a comparison intervention (no acupuncture, conventional rehabilitation alone) in improving functional independence in patients with stroke.

Health-related quality of life (HRQoL)
Effective
1b

One high quality RCT (Sallstrom et al., 1996; and Kjendahl et al., 1997 follow-up study) and one fair quality RCT (Hegyi & Szigeti, 2012) investigated the effect of acupuncture on HRQoL in patients with stroke.

The high quality RCT (Sallstrom et al., 1996) randomized patients with acute/subacute stroke to receive electroacupuncture or no acupuncture; both groups received conventional rehabilitation. HRQoL was measured by the Nottingham Health Profile (NHP – Part I, Part II) at post-treatment (6 weeks) and at 1 year post-discharge from hospital (Kjendahl et al., 1997 follow-up study). Significant between-group differences were found at post-treatment (NHP Part I: sleep, energy) and at follow-up (NHP Part I: emotion, sleep, physical movement, energy; Part II), favoring electroacupuncture vs. no acupuncture.

The fair quality RCT (Hegyi & Szigeti, 2012) randomized patients with acute/subacute stroke to receive acupuncture or no acupuncture for the time of hospitalization (duration not specified); both groups received conventional physical therapy. HRQoL (general and physical statuses) was measured by Visual Analogue Scale at 2 years post-stroke. A significant between-group difference was found, favoring acupuncture vs. no acupuncture.

Conclusion: There is moderate evidence (Level 1b) from one high quality RCT and one fair quality RCT that electroacupuncture is more effective than a comparison intervention (no acupuncture) in improving health-related quality of life in patients with stroke.

Insomnia
Effective
1b

One high quality RCT (Kim et al., 2004) investigated the effect of acupuncture on insomnia in patients with stroke. This high quality RCT randomized patients with stroke (stage of recovery not specified) and insomnia to receive intradermal acupuncture or sham acupuncture. Symptoms of insomnia were measured by the Morning Questionnaire (MQ – sleep latency, sleep quality, condition upon awakening, ability to concentrate, ease of falling asleep, morning sleepiness), the Insomnia Severity Index (ISI) and the Athens Insomnia Scale (AIS) at mid-treatment (1 day) and post-treatment (2 days). Significant between-group differences were found at both time points (MQ – sleep quality, condition upon awakening, ability to concentrate, morning sleepiness; ISI; AIS), favoring intradermal acupuncture vs. sham acupuncture.

Conclusion: There is moderate evidence (Level 1b) from one high quality RCT that acupuncture is more effective than a comparison intervention (sham acupuncture) in improving symptoms of insomnia in patients with stroke and insomnia.

Joint pain
Not effective
1b

One high quality RCT (Alexander et al., 2004) investigated the effect of acupuncture on joint pain in patients with stroke. This high quality RCT randomized patients with acute/subacute stroke to receive acupuncture for 2 weeks or no acupuncture; both groups received conventional rehabilitation. Joint pain was measured by the Fugl-Meyer Assessment (FMA – upper and lower extremity joint pain) at discharge from hospital. No significant between-group differences were found.

Conclusion: There is moderate evidence (Level 1b) from one high quality RCT that acupuncture is not more effective than a comparison intervention (no acupuncture) in improving joint pain in patients with stroke.

Mobility
Effective
2a

One fair quality RCT (Hegyi & Szigeti, 2012) investigated the effect of acupuncture on mobility in patients with stroke. This fair quality RCT randomized patients with acute/subacute stroke to receive acupuncture or no acupuncture for the time of hospitalization (duration not specified); both groups received conventional physical therapy. Mobility was measured by the Rivermead Mobility Index at 2 years post-stroke. Significant between-group differences were found, favoring acupuncture vs. no acupuncture.

Conclusion: There is limited evidence (Level 2a) from one fair quality RCT that acupuncture is more effective than a comparison intervention (no acupuncture) in improving mobility in patients with stroke.

Motor function
Not effective
1a

Three high quality RCTs (Sallstrom et al., 1996; and Kjendahl et al., 1997 follow-up study), Alexander et al., 2004, Zhuang et al., 2012) investigated the effect of acupuncture on motor function in patients with stroke.

The first high quality RCT (Sallstrom et al., 1996) randomized patients with acute/subacute stroke to receive electroacupuncture or no acupuncture; both groups received conventional rehabilitation. Motor function was measured by the Motor Assessment Scale at post-treatment (6 weeks) and at 1 year post-discharge from hospital (Kjendahl et al., 1997 follow-up study). Significant between-group differences were found, at both time points, favoring electroacupuncture vs. no acupuncture.

The second high quality RCT (Alexander et al., 2004) randomized patients with acute/subacute stroketo receive acupuncture for 2 weeks or no acupuncture; both groups received conventional rehabilitation. Motor function was measured by the Fugl-Meyer Assessment (FMA-total) at discharge from hospital. No significant between-group differences were found.

The third high quality RCT (Zhuang et al., 2012) randomized patients with acute/subacute stroke to receive acupuncture, conventional rehabilitation or combined acupuncture with conventional rehabilitation. Motor function was measured by the FMA at mid-treatment (2 weeks) and at post-treatment (4 weeks). No significant between-group differences were found at either time point.

Conclusion: There is strong evidence (Level 1a) from two high quality RCTs that acupuncture is not more effective than a comparison intervention (no acupuncture, conventional rehabilitation) in improving motor function in patients with stroke.
Note:
However, one high quality RCT found that acupuncture was more effective than a comparison intervention (no acupuncture) in improving motor function in patients with stroke.

Motor function (lower extremity)
Effective
1b

One high quality RCT (Alexander et al., 2004) investigated the effect of acupuncture on lower extremity motor function in patients with stroke. This high quality RCT randomized patients with acute/subacute stroke to receive acupuncture for 2 weeks or no acupuncture; both groups received conventional rehabilitation. Lower extremity motor function was measured by the Fugl-Meyer Assessment (FMA – lower extremity motor function) at discharge from hospital. Significant between-group differences were found, favoring acupuncture vs. no acupuncture.

Conclusion: There is moderate evidence (Level 1b) from one high quality RCT that acupuncture is more effective than a comparison intervention (no acupuncture) in improving lower extremity motor function in patients with stroke.

Motor function (upper extremity)
Not effective
1b

One high quality RCT (Alexander et al., 2004) investigated the effects of acupuncture on upper extremity motor function in patients with stroke. This high quality RCT randomized patients with acute/subacute stroke to receive acupuncture for 2 weeks or no acupuncture; both groups received conventional rehabilitation. Upper extremity motor function was measured by the Fugl-Meyer Assessment (FMA – Upper extremity motor function) at discharge from hospital. No significant between-group differences were found.

Conclusion: There is moderate evidence (Level 1b) from one high quality RCT that acupuncture is not more effective than a comparison intervention (no acupuncture) in improving upper extremity motor function in patients with stroke.

Range of motion
Not effective
1b

One high quality RCT (Alexander et al., 2004) investigated the effect of acupuncture on range of motion in patients with stroke. This high quality RCT randomized patients with acute/subacute stroke to receive acupuncture for 2 weeks or no acupuncture; both groups received conventional rehabilitation. Joint motion was measured by the Fugl-Meyer Assessment (FMA – upper/lower extremity joint motion) at discharge from hospital. No significant between-group differences were found.

Conclusion: There is moderate evidence (Level 1b) from one high quality RCT that acupuncture is not more effective than no acupuncture in improving upper and lower extremity range of motion in patients with stroke.

Sensation
Not effective
1b

One high quality RCT (Alexander et al., 2004) investigated the effect of acupuncture on sensation in patients with stroke. This high quality RCT randomized patients with acute/subacute stroke to receive acupuncture for 2 weeks or no acupuncture; both groups received conventional rehabilitation. Sensation was measured by the Fugl-Meyer Assessment (FMA – upper/lower extremity sensation) at discharge from hospital. No significant between-group differences were found.

Conclusion: There is moderate evidence (Level 1b) from one high quality RCT that acupuncture is not more effective than a comparison intervention (no acupuncture) in improving sensation in patients with stroke.

Stroke outcomes
Not effective
1a

Two high quality RCTs (Schuler et al., 2005; Zhuang et al., 2012) investigated the effect of acupuncture on stroke outcomes in patients with stroke.

The first high quality RCT (Schuler et al., 2005) randomized patients with acute/subacute stroke to receive electroacupuncture or placebo acupuncture. stroke outcomes were measured by the European stroke Scale at post-treatment (4 weeks) and at follow-up (6 months). No significant between-group differences were found at either time point.

The second high quality RCT (Zhuang et al., 2012) randomized patients with acute/subacute stroke to receive acupuncture, conventional rehabilitation or combined acupuncture with conventional rehabilitation. stroke outcomes were measured by the Neurologic Defect Scale at mid-treatment (2 weeks) and at post-treatment (4 weeks). No significant between-group differences were found at either time point.

Conclusion: There is strong evidence (Level 1a) from two high quality RCTs that acupuncture is not more effective than comparison interventions (placebo acupuncture, conventional rehabilitation) in improving stroke outcomes in patients with stroke.

Swallowing function
Effective
2b

One fair quality RCT (Mao et al., 2016) investigated the effect of acupuncture on swallowing function in patients with stroke. This fair quality RCT randomized patients with acute/subacute stroke and dysphagia to receive acupuncture + standard swallowing training or standard swallowing training alone. Swallowing function was measured by the Video Fluoroscopic Swallowing Study (VFSS), Standardized Swallowing Assessment (SSA) and the Royal Brisbane Hospital Outcome Measure for Swallowing (RBHOMS) at post-treatment (4 weeks). Significant between-group differences were found in two measures of swallowing function (VSFF, SSA), favoring acupuncture + standard swallowing training vs. standard swallowing training alone.

Conclusion: There is limited evidence (Level 2b) from one fair quality RCT that acupuncture with swallowing training is more effective than a comparison intervention (standard swallowing training alone) in improving swallowing function in patients with stroke.

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Liu, C. H., Hsieh, Y. T., Tseng, H. P., Lin, H. C., Lin, C. L., Wu, T. Y., … & Zhang, H. (2016). Acupuncture for a first episode of acute ischaemic stroke: an observer-blinded randomised controlled pilot study. Acupuncture in Medicine34(5), 349-355.
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Mao, L. Y., Li, L. L., Mao, Z. N., Han, Y. P., Zhang, X. L., Yao, J. X., & Li, M. (2016). Therapeutic effect of acupuncture combining standard swallowing training for post-stroke dysphagia: A prospective cohort study. Chinese Journal of Integrative Medicine22(7), 525-531.
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Min, M., Xin, C., Yuefeng, C., Ping, R., & Jian, L. (2008). Stage-oriented comprehensive acupuncture treatment plus rehabilitation training for apoplectic hemiplegia. Journal of Traditional Chinese Medicine28(2), 90-93.
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Mukherjee M., McPeak L.K., Redford J. B., Sun C., & Liu W. (2007). The effect of electro-acupuncture on spasticity of the wrist joint in chronic stroke survivors. Archives of Physical Medicine and Rehabilitation, 88, 159-166.
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Naeser M.A., Alexander M.P., Stiassny-Eder D., Galler V., Hobbs J., & Bachman D. (1992). Real versus sham acupuncture in the treatment of paralysis in acute stroke patients: a CT scan lesion site study. Journal of Neuroengineering and Rehabilitation 6(4), 163-173.
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Park J., White A.R., James M.A., Hemsley A.G., Johnson P., Chambers J., & Ernst E. (2005). Acupuncture for subacute stroke rehabilitation. A sham-controlled, subject and assessor-blind, randomized trial. Archives of Internal Medicine, 165, 2026-2031.
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Pei, J., Sun, L., Chen, R., Zhu, T., Qian, Y., & Yuan, D. (2001). The effect of electro-acupuncture on motor function recovery in patients with acute cerebral infarction: a randomly controlled trial. Journal of Traditional Chinese Medicine21(4), 270-272.
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Sallstrom S., Kjendahl A., Osten P.E., Stanghelle J.H., & Borchgrevink C.F. (1996). Acupuncture in the treatment of stroke patients in the subacute stage: a randomized, controlled study. Complementary Therapies in Medicine, 4, 193-197.
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Aerobic Exercise

Evidence Reviewed as of before: 30-05-2021
Author(s)*: Tatiana Ogourtsova, PhD OT; Adam Kagan, B.Sc; Anita Petzold, BSc OT; Nathalie Serrat, BSC PT; Amanda Ischayek BSc PT; Sabrina Ianni, BSc, PT; Caroline Labelle, BSc PT; Sukhdeep Johal, Bsc PT; Monica Trozzo BSc. PT; Elissa Sitcoff, BA BSc; Annabel McDermott, OT; Nicol Korner-Bitensky, PhD OT
Expert Reviewer: Janice Eng, PhD PT; Pamela Duncan, PhD PT(C)
Patient/Family Information Table of contents

Introduction

It has been shown that patients with stroke have been shown to have low endurance during exercise, likely due to both the event and also as a secondary reaction to forced inactivity. It is also known that there is a positive connection between aerobic capacity and functional performance (Katz-Leurer et al. 2003).

Click here to view the AEROBICS 2019 Update Best Practice Recommendations.

Click here to access the Canadian Partnership for stroke Recovery (CPSR) 2013 Clinicians’ guide.

Click here to access the CPSR 2013 Patients’ guide.

Patient/Family Information

Authors*: Erica Kader; Adam Kagan, B.Sc.; Nathalie Serrat, BSC PT; Amanda Ischayek BSc PT; Sabrina Ianni, BSc, PT; Caroline Labelle, BSc PT; Sukhdeep Johal, Bsc PT; Monica Trozzo BSc. PT; Elissa Sitcoff, BA BSc; Nicol Korner-Bitensky, PhD OT NOTE: *The authors have no direct financial interest in any tools, tests or interventions presented in StrokEngine.

What is aerobic exercise?

Aerobic exercise refers to physical activity that requires the body to use oxygen to generate energy. Participating in aerobic exercise is important to maintain a healthy body. A major benefit of aerobic exercise is that it conditions the heart and lungs. It does so by increasing the oxygen available to the body and enabling the heart to use oxygen more efficiently. In addition, aerobic exercise can also control body fat, increase energy, decrease tension, increase stamina, and improve mood. There are several different types of aerobic exercises that can be done at different levels of intensity for varying periods of time. Any activity that lasts longer than 3 minutes is considered aerobic (such as golf, biking, walking, and swimming).
Note: While other forms of exercises (such as those focused on flexibility and muscles training) are equally important, only those focusing on aerobic exercise will be addressed in this module.

Why is exercise important after I have had a stroke?

After a stroke, it is common to experience continued difficulties in mobility, for example in walking. It is important to continue to exercise despite these challenges to avoid a vicious cycle, where difficulty in mobility leads to lack of exercise, and lack of exercise leads to further muscle weakening and reduced fitness. Inactivity can contribute to physical complications, including osteoporosis and decreased circulation. It can also lead to loss of independence, depression, and social isolation. The more inactive you are, the harder it is to maintain cardiovascular, mental, and neurological health.

How do I begin to exercise after a stroke?

Before beginning an exercise program, it is recommended that you undergo a comprehensive medical evaluation to assess your specific needs. Your medical or rehabilitation team can work with you to develop an appropriate exercise regime (including types of activities, how often you should participate in activities and for how long) based on your individual needs and abilities.

What kind of activities should I do?

You should pick an activity that you will have fun doing. Examples of aerobic exercise activities include:

  • Golf
  • Walking
  • Dancing – With permission of Dr. Patricia McKinley, McGill School of Physical and Occupational Therapy
  • Swimming
  • Cycling
  • Tennis
  • Bowling

Gardening and housework are also great forms of aerobic exercise. Try adding exercise to your daily routine, for example, parking your car further away from your destination. Any form of physical activity can be beneficial as long as it is done regularly and consistently.

When it comes to bicycling, many people find it difficult or are afraid to fall. This problem can be solved by using a stationary bicycle. Stationary bicycles are a safe and effective means of low-impact, or light, aerobic exercise, so they are a good choice for people who have had a stroke. They can also be altered to fit your individual needs.

Treadmills are also helpful for walking, providing that there is a bar to hold on to, and a way to modify speed and intensity. A treadmill is especially useful to retrain people who have had a stroke to walk again.

Can I participate in the same exercise as before?

After a stroke, it may be difficult to resume the same activities that you enjoyed before. You may need to change your previous exercise regime, which may mean discovering new exercise activities that are perhaps less physically demanding. Things that you may need to modify are:

  • The level of difficulty of exercise
  • Length of time you exercise
  • How often you exercise

These will depend on your needs and abilities and should be assessed by a rehabilitation team. Certain equipment can also be used to facilitate exercising, such as handrails and assistive devices. For example, you may enjoy swimming but may need to find a pool that has special safety equipment and adaptations.

Who can help me resume my exercise activities?

While rehabilitation staff, such as occupational therapists, physiotherapists, social workers, recreation therapists, and psychologists will start you on your new exercise program, your family and friends are an excellent source of support to help you continue with success. Exercising with a friend or family member is motivating, encouraging, and of course more fun.

How much exercise should I do?

According to the American Heart Association, the recommended frequency of training is 3 to 7 days a week, with a duration of 20 to 60 minutes per day, depending on the patient’s level of fitness. ** Once again, however, it is very important that you seek medical advice before beginning an exercise program and get advice on how often and for how long you should be doing the activities.

Where can I participate in exercise?

While in the hospital or rehabilitation centre, you will participate in exercise programs developed and assisted by your rehabilitation team. When you are ready to go home, the team may show you how to continue with this exercise on your own, may recommend that you join an exercise program, or a combination of the two. Day centers, local community centers, and gyms in your area may be able to provide appropriate programs and support that you need.

Is it effective after stroke?

Experts have done some experiments to compare aerobic exercise with other treatments to see whether it helps people who have had a stroke.

In individuals with ACUTE stroke (< 4 weeks after stroke)

Studies found that aerobic exercise:

  • Was more helpful than the other treatments for improving awareness about stroke and walking endurance (i.e. your physical tolerance when walking).
  • Was as helpful as other treatments for improving cardiovascular fitness parameters (e.g. your blood pressure); quality of life; mood and affect (e.g. symptoms of depression and/or anxiety); and physical activity.

In individuals with CHRONIC stroke (> 6 months after stroke)

Studies found that aerobic exercise:

  • Was more helpful than the other treatments for improving cognitive function (e.g. memory, attention); grip strength; quality of life; walking endurance (i.e. physical tolerance when walking); and walking speed.
  • Was as helpful as other treatments for improving balance; cardiovascular fitness parameters (e.g. your blood pressure); executive functions (e.g. your ability to plan and sequence tasks); functional independence (i.e. your ability to perform tasks of daily life such as dressing and washing); mobility (walking, going up/down the stairs); mood and affect (e.g. symptoms of depression and/or anxiety); the strength of your leg muscles; and physical activity.

In individuals with stroke (unspecified time period post-stroke)

Studies found that aerobic exercise:

  • Was more helpful than the other treatments for improving balance; cardiovascular fitness parameters (e.g. your blood pressure); functional independence (your ability to perform tasks of everyday life such as dressing and washing); quality of life; the function of your legs and overall function of your body; spasticity (the tone of your muscles); walking endurance (your physical tolerance when walking); and walking speed.
  • Was as helpful as other treatments for improving cognitive abilities (e.g. memory, attention); dexterity (ability to manipulate small objects with your fingers); capacity to exercise; executive function (e.g. your ability to plan and sequence tasks); depression; fatigue; mobility (ability to move around); muscle strength; and the quality of sleep.

Are there any side effects or risks?

While exercise is mostly risk-free, it is important to stay within your own personal threshold. As mentioned before, it is best to consult with your doctor or therapist before beginning an exercise program. They will assist you in determining how often you should exercise, what activities you should participate in, and how intense they should be. If you were physically active before the stroke, you may or may not be able to continue with the same activities. You may simply need to modify those activities so they are easier for you. If you feel dizzy, have pain (especially in your chest) or have difficulty breathing, stop exercising immediately and tell your healthcare provider.

Clinician Information

Note: When reviewing the findings, it is important to note that they are always made according to randomized clinical trial (RCT) criteria – specifically as compared to a control group. To clarify, if a treatment is “effective” it implies that it is more effective than the control treatment to which it was compared. Non-randomized studies are no longer included when there is sufficient research to indicate strong evidence (level 1a) for an outcome.
Note: It is often difficult to say with absolute certainty whether a particular exercise intervention is “aerobic” in nature. In this module we include only those studies that had a clear aerobic exercise intervention. Specifically only those that included an outcome examining the effect of exercise on aerobic capacity (peak VO2, peak workload and peak heart rate during some sort of maximal aerobic test) were considered. Many of these studies also examined functional, physical and emotional outcomes and these results are included. As well, many studies to date that have examined the effect of aerobic exercise featured a “cocktail” of different types of treatment (e.g. strength training, flexibility training as well as a strong aerobic training component) so it is important to note that the effects of these interventions may be due in part to the combination of different treatments and not the aerobic component specifically.

This module focuses on aerobic exercise for people who have had a stroke. This module contains 16 studies, where 11 of them are of high quality. Three studies report effects of aerobic exercise for individuals early in their stroke recovery period (1 month or less after stroke). Nine studies report effects of aerobic exercise for individuals in their chronic stroke period (6 months or more after stroke). Four studies report effects of aerobic exercise for individuals after stroke with unspecified period.

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Results Table

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Outcomes

Acute phase

Cardiovascular fitness parameters
Not effective
1b

One high quality RCT (Wijkman et al., 2017) investigated the effect of aerobic exercise on cardiovascular fitness parameters in the acute phase of stroke recovery. This high quality RCT randomized patients to receive aerobic exercise or no scheduled physical exercise. Cardiovascular fitness parameters [Resting diastolic blood pressure, Resting systolic blood pressure (SBP), Peak SBP, Difference in SBP (peak – resting), Resting heart rate, Peak heart rate, Difference in heart rate (peak – resting), Aerobic capacity work rate] were measured by ergometer exercise test at post-treatment (12 weeks). No significant between-group differences were found.

Conclusion: There is moderate evidence (Level 1b) from one high quality RCT that aerobic exercise is not more effective than a comparison intervention (usual care without scheduled physical exercise) in improving cardiovascular fitness parameters in the acute phase of stroke recovery.

Health-related quality of life
Conflicting
4

Two high quality RCTs (Faulkner et al., 2015; Moren et al., 2016) investigated the effect of aerobic exercise on health-related quality of life (HRQoL) in the acute phase of stroke recovery.

The first high quality RCT (Faulkner et al., 2015) randomized patients to receive a resistance exercise and education program or written information. HRQoL was measured by the Short-Form 36 (SF-36: Physical component score, Mental component score, Mental health, Social functioning, Global health, Role physical, Role emotional, Vitality, Bodily pain, Physical functioning) at post-treatment (8 weeks) and follow-up (12 months). Significant between-group differences were found in change scores from baseline to post-treatment in some components of HRQoL (Physical component score, Global health, Role physical, Vitality, Physical Functioning), favouring exercise + education vs. written information. Differences did not remain significant at follow-up.

The second high quality RCT (Moren et al., 2016) randomized patients to receive physical activity or no treatment; both groups received usual care. HRQoL was measured by the EuroQoL 5 Dimension Visual Analogue Scale at follow-up (3 and 6 months). No significant between-group difference was found at either time point.

Conclusion: There is conflicting evidence (Level 4) regarding the effect of aerobic exercise on HRQoL in the acute phase of stroke recovery. While one high quality RCT found that an exercise + education program was more effective than written information alone, another high quality RCT found that physical activity was not more effective than no treatment.
Note:
Differences in outcome measures may explain the conflicting findings.

Mood and affect
Not effective
1b

One high quality RCT (Faulkner et al., 2015) investigated the effect of aerobic exercise on mood and affect in the acute phase of stroke recovery. This high quality RCT randomized patients to receive a resistance exercise and education program or written information. Mood and effect were measured by the Hospital Anxiety and Depression Scale (HADS: Anxiety, Depression) and the Profile and Mood States (PMS: Vigour, Depression, Confusion, Tension, Anger, Fatigue) at post-treatment (8 weeks) and follow-up (12 months). A significant between-group difference was found in change scores from post-treatment to follow-up in one measure (PMS: Fatigue), favouring exercise + education vs. written information. No other significant between-group differences were found at either time point.

Conclusion: There is moderate evidence (Level 1b) from one high quality RCT that aerobic exercise is not more effective than a comparison intervention (written information) in improving mood and affect in the acute phase of stroke recovery.

Physical activity
Not Effective
1a

Two high quality RCTs (Faulkner et al., 2015; Moren et al., 2016) investigated the effect of aerobic exercise on physical activity in the acute phase of stroke recovery.

The first high quality RCT (Faulkner et al., 2015) randomized patients to receive a resistance exercise and education program or written information. Physical activity was measured by the International Physical Activity Questionnaire (IPAQ: Leisure time walk activity, Leisure time moderate activity, Leisure time vigorous activity, Total leisure time activity, Sitting time) at post-treatment (8 weeks) and follow-up (12 months). No significant between-group difference was found at either time point.

The second high quality RCT (Moren et al., 2016) randomized patients to receive physical activity or no treatment; both groups received usual care. Physical activity was measured by the Physical Activity of Moderate to Higher Intensity (MVPA) and number of steps per day at follow-up (3 and 6 months). No significant between-group differences were found at either time point.

Conclusion: There is strong evidence (Level 1a) from two high quality RCTs that aerobic exercise is not more effective than a comparison intervention (written information) or no treatment in improving physical activity in the acute phase of stroke recovery.

Sroke awareness
Effective
1b

One high quality RCT (Faulkner et al., 2015) investigated the effect of aerobic exercise on stroke awareness in the acute phase of stroke recovery. This high quality RCT randomized patients to receive a resistance exercise and education program or written educational material. stroke awareness was measured by the Stanford Medical Centre stroke Awareness Questionnaire (SMCSAQ) at post-treatment (8 weeks) and follow-up (12 months). A significant between-group difference was found in change scores from baseline to post-treatment, favouring exercise + education vs. written educational material. Differences did not remain significant at follow-up.

Conclusion: There is moderate evidence (Level 1b) from one high quality RCT that aerobic exercise is more effective than a comparison intervention (written educational material) in improving stroke awareness in the acute phase of stroke recovery.

Walking endurance
Effective
1b

One high quality RCT (Moren et al., 2016) investigated the effect of aerobic exercise on walking endurance in the acute phase of stroke recovery. This high quality RCT randomized patients to receive physical activity or no treatment; both groups received usual care. Walking endurance was measured by the 6 Minute Walk Test at follow-up (3 and 6 months). A significant between-group difference was found at 6-month follow-up, favouring physical activity vs. no treatment.

Conclusion: There is moderate evidence (Level 1b) from one high quality RCT that physical activity is more effective than no treatment in improving long-term walking endurance of patients in the acute phase of stroke recovery.

Chronic phase

Balance
Conflicting
4

Four high quality RCTs (Pang et al., 2005; Liu-Ambrose & Eng, 2015; Lee et al., 2015; Moore et al., 2015) and one fair quality RCT (Lund et al., 2018) investigated the effect of aerobic exercise on balance in the chronic stage of stroke recovery.

The first high quality RCT (Pang et al., 2005) randomized patients to receive a community-based fitness and mobility exercise program (FAME) or a seated upper extremity program. Balance was measured by the Berg Balance Scale (BBS) at post-treatment (19 weeks). No significant between group difference was found.

The second high quality RCT (Liu-Ambrose & Eng, 2015) randomized patients to receive the FAME program or usual care. Balance was measured by the BBS at mid-treatment (3 months) and post-treatment (6 months). No significant between group difference was found at either time point.

The third high quality RCT (Lee et al., 2015) randomized patients to receive aerobic + resistance exercise training or light physical activity. Balance was measured by the Chair Sit and Reach Test and the Functional Reach Test at post-treatment (16 weeks). Significant between-group differences were found in both measures of balance, favouring aerobic + resistance exercise training vs. light physical activity.

The fourth high quality RCT (Moore et al., 2015) randomized patients to receive a fitness and mobility exercise program (adapted from the FAME program) or time-matched stretching. Balance was measured by the BBS at post-treatment (19 weeks). A significant between-group difference was found, favouring the fitness and mobility exercise program vs. stretching.

The fair quality RCT (Lund et al., 2018) randomized patients to receive aerobic training, resistance training or upper extremity training. Balance was measured by the BBS at post-treatment (12 weeks). No significant between-group differences were found.

Conclusion: There is conflicting evidence (Level 4) regarding the effectiveness of aerobic exercise in improving balance in the chronic stage of stroke recovery. While two high quality RCTs found that the FAME exercise program was not more effective than comparison interventions (seated upper extremity program, usual care), two high quality RCTs found that other aerobic exercise programs (aerobic + resistance exercise training, exercises adapted from the FAME program) were more effective than comparison interventions (light physical activity, stretching).

Cardiovascular fitness parameters
Conflicting
4

Five high quality RCTs (Pang et al., 2005; Gordon, Wilks & McCaw-Binns, 2013; Tang et al., 2014 and 2016; Lee et al., 2015; Moore et al., 2015) and two fair quality RCTs (Severinsen et al., 2014; Lund et al., 2018) investigated the effect of aerobic exercise on cardiovascular fitness parameters in the chronic stage of stroke recovery.

The first high quality RCT (Pang et al., 2005) randomized patients to receive a community-based fitness and mobility exercise program (FAME) or a seated upper extremity program. Maximal oxygen consumption was measured by the maximal exercise test on the Excalibur cycle ergometer at post-treatment (19 weeks). A significant between-group difference was found, favouring the FAME program vs. seated upper extremity exercises.

The second high quality RCT (Gordon, Wilks & McCaw-Binns, 2013) randomized patients to receive aerobic exercise or massage. Resting heart rate was measured by heart monitor at post-treatment (12 weeks) and follow-up (3 months). A significant between-group difference was found at follow-up only, favouring aerobic exercise vs. massage.

The third high quality RCT (Tang et al., 2014; 2016) randomized patients to receive aerobic training or balance/flexibility training. Peak oxygen consumption was measured by graded maximal exercise test using a leg cycle ergometer at post-treatment (6 months). No significant between-group difference was found.

The fourth high quality RCT (Lee et al., 2015) randomized patients to receive aerobic + resistance exercise training or light physical activity. Cardiovascular parameters (peripheral systolic blood pressure (SBP) / diastolic blood pressure (DBP), central SBP / DBP, Pulse Wave Velocity (PWV), Augmentation Index – AIx@75) were measured at post-treatment (16 weeks). Significant between-group differences were found for three cardiovascular fitness parameters (central DBP, PWV, AIx@75), favouring aerobic + resistance training vs. light physical activity.

The fifth high quality RCT (Moore et al., 2015) randomized patients to receive a fitness and mobility exercise program or time-matched stretching. Cardiovascular parameters (Peak oxygen consumption, Peak work rate, SBP, DBP) were measured by the maximal progressive recumbent bicycle exercise test and the semi-automated sphygmomanometer at post-treatment (19 weeks). Significant between-group differences were found for three cardiovascular fitness parameters (Peak oxygen consumption, Peak work rate, DBP), favouring the fitness and mobility exercise program vs. stretching.

The first fair quality RCT (Severinsen et al., 2014) randomized patients to receive aerobic training, resistance training or upper extremity training. Peak aerobic capacity (VO2 peak) was measured by the maximal progressive stepwise cycle ergometer test at post-treatment (12 weeks) and at follow-up (6 months). Significant between-group differences were found at post-treatment, favouring aerobic training vs. resistance training and aerobic training vs. upper extremity training; differences were not maintained at follow-up.

The second fair quality RCT (Lund et al., 2018) randomized patients to receive aerobic training, resistance training or upper extremity training. Cardiovascular fitness parameters (peak oxygen update, resting HR, maximal HR) were measured by the maximal progressive cycle ergometer test and a heart rate monitor at post-treatment (12 weeks). No significant between-group differences were found.

Conclusion: There is conflicting evidence (Level 4) regarding the effectiveness of aerobic exercise programs on cardiovascular fitness in the chronic phase of stroke recovery. While three high quality RCTs and one fair quality RCT found that aerobic exercise programs were more effective than comparison interventions (seated upper extremity exercises, light physical activity, stretching, resistance training, upper extremity training), two high quality RCTs* and one fair quality RCT found that aerobic exercise programs were not more effective than comparison interventions (massage, balance/flexibility training, upper extremity training).
*Note:
One of the high quality RCTs found that aerobic exercises were more effective than massage in the long-term.

Cognition
Effective
1b

One high quality RCT (Moore et al., 2015) investigated the effect of aerobic exercise on cognition in the chronic stage of stroke recovery. This high quality RCT randomized patients to receive a fitness and mobility exercise program or stretching. Cognition was measured by the Addenbrooke’s Cognitive Examination Revised at post-treatment (19 weeks). A significant between-group difference was found, favouring the fitness and mobility exercise program vs. stretching.

Conclusion: There is moderate evidence (Level 1b) from one high quality RCT that aerobic exercise is more effective than a comparison intervention (stretching) in improving cognition in the chronic stage of stroke recovery.

Executive functions
Conflicting
4

Two high quality RCTs (Tang et al., 2014 & 2016; Liu-Ambrose & Eng, 2015) investigated the effect of aerobic exercise on executive functions in the chronic stage of stroke recovery.

The first high quality RCT (Tang et al., 2014 & 2016) randomized patients to receive aerobic training or balance/flexibility training. Executive functions were measured by the Verbal Digit Span Test Forward & Backward (working memory), Trail Making Test B (set shifting), and Colour-Word Stroop Test (selective attention and conflict resolution) at post-treatment (6 months). No significant between-group differences were found.

The second high quality RCT (Liu-Ambrose & Eng, 2015) randomized patients to receive a community-based Fitness and Mobility Exercise (FAME) program or usual care. Executive functions were measured by the Stroop Test (selective attention and conflict resolution), Trail Making Tests – Part A and B (set shifting) and verbal digit span forward/backward test (working memory) at mid-treatment (3 months) and post-treatment (6 months). At mid-treatment a significant between-group difference was found in one measure of executive functions (Trail Making Tests), favouring the FAME program vs. usual care. At post-treatment significant between-group differences were found in two measures of executive functions (Stroop Test; verbal digit span forward/backward test), favouring the FAME program vs. usual care.

Conclusion: There is conflicting evidence (Level 4) regarding the effectiveness of aerobic exercise in improving executive functions in the chronic stage of stroke recovery. One high quality RCT found that aerobic training was not more effective than a balance/flexibility program, whereas another high quality RCT found that aerobic exercise was more effective than usual care.

Functional independence
Not effective
1b

One high quality RCT (Gordon, Wilks & McCaw-Binns, 2013) investigated the effect of aerobic exercise on functional independence in the chronic stage of stroke recovery. This high quality RCT randomized patients to receive aerobic exercise or massage. Functional independence was measured by the Barthel Index at post-treatment (12 weeks) and follow-up (3 months). No significant between-group difference was found at either time point.

Conclusion: There is moderate evidence (Level 1b) from one high quality RCT that aerobic exercise is not more effective than a comparison intervention (massage) in improving functional independence in the chronic stage of stroke recovery.

Functional status and service use
Not effective
1b

One high quality RCT (Gordon, Wilks & McCaw-Binns, 2013) investigated the effect of aerobic exercise on functional status and service use in the chronic stage of stroke recovery. This high quality RCT randomized patients to receive aerobic exercise or massage. Functional status and service use were measured by the Older Americans Resources and Services at post-treatment (12 weeks) and follow-up (3 months). No significant between-group difference was found at either time point.

Conclusion: There is moderate evidence (Level 1b) from one high quality RCT that aerobic exercise is not more effective than a comparison intervention (massage) in improving functional status and service use in the chronic stage of stroke recovery.

Grip strength
Effective
1b

One high quality RCT (Lee et al., 2015) investigated the effect of aerobic exercise on grip strength in the chronic stage of stroke recovery. This high quality RCT randomized patients to receive aerobic + resistance exercise training or light physical activity. Grip strength of the unaffected hand was measured by handheld dynamometer at post-treatment (16 weeks). A significant between-group difference was found, favouring aerobic + resistance exercise training vs. light physical activity.

Conclusion: There is moderate evidence (Level 1b) from one high quality RCT that aerobic exercise with resistance training is more effective than a comparison intervention (light physical activity) in improving grip strength of the unaffected hand in the chronic stage of stroke recovery.

Health-related quality of life
Effective
1b

One high quality RCTs (Gordon, Wilks & McCaw-Binns, 2013) investigated the effect of aerobic exercise on health-related quality of life (HRQoL) in the chronic stage of stroke recovery. This high quality RCT randomized patients to receive aerobic exercise or massage. HRQoL was measured by the Short-Form-36 (SF-36: Physical health component, Mental health component) at post-treatment (12 weeks) and follow-up (3 months). A significant between-group difference was found at post-treatment (SF-36: Physical health component), favouring aerobic exercise vs. massage.

Conclusion: There is moderate evidence (Level 1b) from one high quality RCT that aerobic exercise is more effective than a comparison intervention (massage) in improving health-related quality of life in the chronic stage of stroke recovery.
Note:
Between-group differences were only significant for one measure of health-related quality of life.

Mobility
Not effective
1b

One high quality RCT (Lee et al., 2015) investigated the effect of aerobic exercise on mobility in the chronic stage of stroke recovery. This high quality RCT randomized patients to receive aerobic and resistance exercise training or light physical activity. Mobility was measured by the Timed Up and Go Test at post-treatment (16 weeks). No significant between-group difference was found.

Conclusion: There is moderate evidence (Level 1b) from one high quality RCT that aerobic exercise is not more effective than a comparison intervention (light physical activity) in improving mobility in the chronic stage of stroke recovery.

Mood and affect
Not effective
1b

One high quality RCT (Liu-Ambrose & Eng, 2015) investigated the effect of aerobic exercise on mood and affect in the chronic stage of stroke recovery. This high quality RCT randomized patients to receive a community-based Fitness and Mobility Exercise (FAME) program or usual care. Mood and affect were measured by the 17-item stroke Specific Geriatric Depression Scale at mid-treatment (3 months) and post-treatment (6 months). No significant between-group difference was found at either time point.

Conclusion: There is moderate evidence (Level 1b) from one high quality RCT that aerobic exercise is not more effective than a comparison intervention (usual care) in improving mood and affect in the chronic stage of stroke recovery.

Muscle strength - lower extremities
Conflicting
4

Three high quality RCTs (Pang et al., 2005; Gordon, Wilks & McCaw-Binns, 2013; Lee et al., 2015) and two fair quality RCTs (Severinsen et al., 2014; Lund et al., 2018) investigated the effect of aerobic exercise on lower extremities muscle strength in the chronic stage of stroke recovery.

The first high quality RCT (Pang et al., 2005) randomized patients to receive a community-based fitness and mobility exercise program (FAME) or a seated upper extremity program. Isometric knee extension (paretic, non-paretic) was measured by dynamometer at post-treatment (19 weeks). A significant between group difference was found, favouring the FAME program vs. seated upper extremity exercises.

The second high quality RCT (Gordon, Wilks & McCaw-Binns, 2013) randomized patients to receive aerobic exercise or massage. Lower extremity strength (paretic, non-paretic) was measured by the Motricity Index at post-treatment (12 weeks) and follow-up (3 months). No significant between-group difference was found at either time point.

The third high quality RCT (Lee et al., 2015) randomized patients to receive aerobic + resistance exercise training or light physical activity. Lower extremity strength was measured by the 30-sec Chair Stand Test at post-treatment (16 weeks). A significant between-group difference was found, favouring aerobic + resistance exercise training vs. light physical activity.

The first fair quality RCT (Severinsen et al., 2014) randomized patients to receive aerobic training, resistance training or upper extremity training. Maximal isometric knee strength (paretic, non-paretic) was measured by dynamometer at post-treatment (12 weeks) and follow-up (6 weeks). A significant between-group difference in knee strength (paretic, non-paretic) was found at post-treatment, favouring resistance training vs. aerobic training; this between-group difference was maintained at follow-up. There was no significant difference in knee strength between aerobic training vs. upper extremity training.
Note: A significant between-group difference in knee strength (non-paretic only) was found at post-treatment, favouring resistance training vs. upper extremity exercises; this difference was maintained at follow-up.

The second fair quality RCT (Lund et al., 2018) randomized patients to receive aerobic training, resistance training or upper extremity training. Knee strength (paretic, non-paretic) was measured by dynamometer at post-treatment (12 weeks). No significant between-group differences were found.

Conclusion: There is conflicting evidence (Level 4) regarding the effectiveness of aerobic exercise on lower extremity strength in the chronic stage of stroke recovery. While two high quality RCTs found that aerobic exercise was more effective than comparison interventions (seated upper extremity program, light physical activity), one high quality RCT and two fair quality RCTs found that aerobic exercise was not more effective than comparison interventions (massage, upper extremity training, resistance training).
Note
: In fact, one of the fair quality RCTs found that resistance training was more effective than aerobic training for improving knee strength.

Physical activity
Not effective
1b

One high quality RCT (Pang et al., 2005) and one fair quality RCT (Shaughnessy, Michael & Resnick, 2012) investigated the effect of aerobic exercise on physical activity in the chronic stage of stroke recovery.

The high quality RCT (Pang et al., 2005) randomized patients to receive a community-based fitness and mobility exercise program (FAME) or a seated upper extremity program. Physical activity was measured by the Physical Activity Scale for Individuals with Physical Disabilities at post-treatment (19 weeks). No significant between group difference was found.

The fair quality RCT (Shaughnessy, Michael & Resnick, 2012) randomized patients to receive aerobic treadmill training or stretching. Physical activity was measured by the Yale Physical Activity Survey (YPAS: Housework, Yard work, Caretaking, Moderate physical activity, Recreational activities) at post-treatment (6 months). No significant between-group difference was found.

Conclusion: There is moderate evidence (Level 1b) from one high quality RCT and one fair quality RCT that aerobic exercise is not more effective than comparison interventions (seated upper extremity program, stretching) in improving physical activity in the chronic stage of stroke recovery.

Self-efficacy and expectations
Not effective
2a

One fair quality RCT (Shaughnessy, Michael & Resnick, 2012) investigated the effect of aerobic exercise on self-efficacy & expectations in the chronic stage of stroke recovery. This fair quality RCT randomized patients to receive aerobic treadmill training or stretching. Self-efficacy & expectations were measured by Short Self-Efficacy and Outcomes Expectations for Exercises (Outcome expectations; Self-efficacy) at post-treatment (6 months). No significant between-group difference was found.

Conclusion: There is limited evidence (Level 2a) from one fair quality RCT that aerobic exercise is not more effective than a comparison intervention (stretching) in improving self-efficacy & expectations in the chronic stage of stroke recovery.

Stroke outcomes
Not effective
1b

One high quality RCT (Moore et al., 2015) and one fair quality RCT (Shaughnessy, Michael & Resnick, 2012) investigated the effect of aerobic exercise on stroke outcomes in the chronic stage of stroke recovery.

The high quality RCT (Moore et al., 2015) randomized patients to receive a fitness and mobility exercise program or time-matched stretching. stroke outcomes were measured by the stroke Impact Scale (SIS: stroke recovery, Mood, Strength, Memory, Communication, Activities of daily living, Community mobility, Hand function, Participation, Physical total) at post-treatment (19 weeks). A significant between-group difference was found in only one measure (SIS: Mood), favouring the fitness and mobility exercise program vs. stretching.

The fair quality RCT (Shaughnessy, Michael & Resnick, 2012) randomized patients to receive aerobic treadmill training or stretching. stroke outcomes were measure by the SIS (Strength, Hand function, Activities of daily living, Mobility, Communication, Emotion, Memory and thinking, Participation, Overall sum, Recovery visual analogue scale) at post-treatment (6 months). No significant between-group difference was found.

Conclusion: There is moderate evidence (Level 1b) from one high quality RCT and one fair quality RCT that aerobic exercise is not more effective than a comparison intervention (stretching) in reducing stroke outcomes in the chronic stage of stroke recovery.

Walking endurance
Effective
1a

Six high quality RCTs (Pang et al., 2005; Gordon, Wilks & McCaw-Binns, 2013; Tang et al., 2014 & 2016; Lee et al., 2015; Liu-Ambrose & Eng, 2015; Moore et al., 2015) and 2 fair quality RCTs (Severinsen et al., 2014; Lund et al., 2018) investigated the effect of aerobic exercise on walking endurance in the chronic stage of stroke recovery.

The first high quality RCT (Pang et al., 2005) randomized patients to receive a community-based fitness and mobility exercise program (FAME) or a seated upper extremity program. Walking endurance was measured by the 6-Minute Walk Test (6MWT) at post-treatment (19 weeks). A significant between-group difference was found, favouring the FAME program vs. seated upper extremity exercises.

The second high quality RCT (Gordon, Wilks & McCaw-Binns, 2013) randomized patients to receive aerobic exercise or massage. Walking endurance was measured by the 6MWT at post-treatment (12 weeks) and follow-up (3 months). No significant between-group differences were found at either time point.

The third high quality RCT (Tang et al., 2014; 2016) randomized patients to receive aerobic training or balance/flexibility training. Walking endurance was measured by the 6MWT at post-treatment (6 months). No significant between-group difference was found.

The fourth high quality RCT (Lee et al., 2015) randomized patients to receive aerobic + resistance exercise training or light physical activity. Walking endurance was measured by the 6MWT at post-treatment (16 weeks). A significant between-group difference was found, favouring aerobic + resistance exercise training vs. light physical activity.

The fifth high quality RCT (Liu-Ambrose & Eng, 2015) randomized patients to receive the FAME program or usual care. Walking endurance was measured by the 6MWT at mid-treatment (3 months) and post-treatment (6 months). A significant between-group difference was found at post-treatment, favouring the FAME program vs. usual care.

The sixth high quality RCT (Moore et al., 2015) randomized patients to receive a fitness and mobility exercise program or time-matched stretching. Walking endurance was measured by the 6MWT at post-treatment (19 weeks). A significant between-group difference was found, favouring the fitness and mobility exercise program vs. stretching.

The first fair quality RCT (Severinsen et al., 2014) randomized patients to receive aerobic training, resistance training or upper extremity training. Walking endurance was measured by the 6MWT at post-treatment (12 weeks) and at follow-up (6 months). No significant between-group differences were found.

The second fair quality RCT (Lund et al., 2018) randomized patients to receive aerobic training, resistance training or upper extremity training. Walking endurance was measured by the 6MWT at post-treatment (12 weeks). No significant between-group differences were found.

Conclusion: There is strong evidence (Level 1a) from four high quality RCTs that aerobic exercise is more effective than comparison interventions (seated upper extremity program, light physical activity, usual care, stretching) in improving walking endurance in the chronic stage of stroke recovery.
Note
: However, two high quality RCTs and two fair quality RCTs found that aerobic exercise was not more effective than comparison interventions (massage, balance/flexibility training, resistance training, upper extremity training).

Walking speed
Effective
1a

Two high quality RCTs (Lee et al., 2015; Moore et al., 2015) and two fair quality RCTs (Severinsen et al., 2014; Lund et al., 2018) investigated the effect of aerobic exercise on walking speed in the chronic stage of stroke recovery.

The first high quality RCT (Lee et al., 2015) randomized patients to receive aerobic + resistance exercise training or light physical activity. Walking speed was measured by the 10 Meter Walk Test (10mWT) at post-treatment (16 weeks). A significant between-group difference was found, favouring aerobic + resistance exercise training vs. light physical activity.

The second high quality RCT (Moore et al., 2015) randomized patients to receive a fitness and mobility exercise program or time-matched stretching. Walking speed was measured by the 10mWT at post-treatment (19 weeks). A significant between-group difference was found, favouring the fitness and mobility exercise program vs. stretching.

The first fair quality RCT (Severinsen et al., 2014) randomized patients to receive aerobic training, resistance training or upper extremity training. Walking speed was measured by the 10mWT at post-treatment (12 weeks) and at follow-up (6 months). No significant between-group differences were found at post-treatment. Significant between-group differences were found at follow-up, favouring resistance training vs. aerobic training, and upper extremity training vs. aerobic training.

The second fair quality RCT (Lund et al., 2018) randomized patients to receive aerobic training, resistance training or upper extremity training. Walking speed was measured by the 10mWT at post-treatment (12 weeks). No significant between-group differences were found.

Conclusion: There is strong evidence (Level 1a) from two high quality RCTs that aerobic exercise is more effective than comparison interventions (light physical activity, stretching) in improving walking speed in the chronic stage of stroke recovery.
Note: Two fair quality RCTs found that aerobic exercise was not more effective than comparison interventions (resistance training, upper extremity training). In fact, one fair quality RCT found that both resistance training and upper extremity training were more effective than aerobic exercise for improving walking speed.

Phase not specific to one period

Balance
Effective
1b

One high quality RCT (Sandberg et al., 2016) and one quasi-experimental design study (Marsden et al., 2016) investigated the effect of aerobic exercise on balance in patients with stroke.

The high quality RCT (Sandberg et al., 2016) randomized patients with acute/subacute stroke to receive an aerobic exercise program or no exercise program. Balance was measured by the Single Leg Stance Test (SLST: Right/left with eyes closed/open) at post-treatment (12 weeks). A significant between-group difference was found for three measures of balance (SLST: Right leg eyes open, Right leg eyes closed, Left leg eyes open), favouring aerobic exercise program vs. no exercise program.

The quasi-experimental design study (Marsden et al., 2016) assigned patients with acute, subacute or chronic stroke to receive a home- and community-based exercise program with aerobic content or usual care. Balance was measured by the Step Test (Right, Left) at post-treatment (12 weeks). A significant between-group difference was found on both measures of balance, favouring the aerobic exercise program vs. usual care.

Conclusion: There is moderate evidence (Level 1b) from one high quality RCT and one quasi-experimental study that aerobic exercise is more effective than comparison interventions (no exercise program, usual care) in improving balance in patients with stroke.

Cardiovascular fitness parameters
Effective
1a

Two high-quality RCTs (Wang et al., 2014; Sandberg et al., 2016) and one quasi-experimental design study (Marsden et al., 2016) investigated the effect of aerobic exercise on cardiovascular fitness parameters in patients with stroke.

The first high quality RCT (Wang et al., 2014) randomized patients with subacute/chronic stroke to receive low-intensity aerobic training or no training; both groups received conventional rehabilitation. Cardiovascular fitness parameters (Resting heart rate (RHR), Peak heart rate (PHR), Exercise test time) were measured at post-treatment (6 weeks). A significant between-group difference was found on one measure (exercise test time), in favour of aerobic training vs. no aerobic training.

The second high quality RCT (Sandberg et al., 2016) randomized patients with acute/subacute stroke to receive an aerobic exercise program or no exercise program. A cardiovascular fitness parameter (Peak work rate) was measured by the symptom-limited graded cycle ergometer test at post-treatment (12 weeks). A significant between-group difference was found, favouring aerobic exercise program vs. no exercise program.

The quasi-experimental design study (Marsden et al., 2016) assigned patients with acute, subacute or chronic stroke to receive a home- and community-based exercise program with aerobic content or usual care. Cardiovascular fitness parameters (Vo2peak absolute, Vo2peak relative, HR, R-value) were measured during the 6 Minute Walk Test (6MWT), Shuttle Walk Test and Cycle Progressive Exercise Test (also Duration, Workload measures) at post-treatment (12 weeks). A significant between-group difference was found in one parameter (6MWT: Vo2peak absolute, relative), favouring an aerobic exercise program vs. usual care.

Conclusion: There is strong evidence (Level 1a) from two high quality RCTs and one quasi-experimental study that aerobic exercise is more effective than no treatment for improving some cardiovascular fitness parameters (e.g. exercise test time, peak work rate, peak oxygen uptake) in patients with stroke.

Cognition
Not effective
2b

One fair quality RCT (Nave et al., 2019) investigated the effect of aerobic exercise on cognition in patients with stroke. This fair quality RCT randomized patients with acute/subacute stroke to receive aerobic physical fitness training using the PHYS-STROKE program or relaxation. Cognition was measured by the Montreal Cognitive Assessment at post-treatment (4 weeks) and follow-up (3, 6 months). No significant between group difference was found at any time point.

Conclusion: There is limited evidence (Level 2b) from one fair quality RCT that aerobic exercise is not more effective than a comparison intervention (relaxation) in improving cognition in patients with stroke.

Depression
Not effective
2b

One fair quality RCT (Nave et al., 2019) and one quasi-experimental design study (Marsden et al., 2016) investigated the effect of aerobic exercise on depression in patients with stroke.

The fair quality RCT (Nave et al., 2019) randomized patients with acute/subacute stroke to receive aerobic physical fitness training using the PHYS-STROKE program or relaxation. depression was measured by the Centre for Epidemiological Studies depression at post-treatment (4 weeks) and follow-up (3, 6 months). No significant between-group differences were found at any time points.

The quasi-experimental design study (Marsden et al., 2016) assigned patients with acute, subacute or chronic stroke to receive a home- and community-based exercise program with aerobic content or usual care. depression was measured by the Patient Health Questionnaire-9 at post-treatment (12 weeks). No significant between-group difference was found.

Conclusion: There is limited evidence (Level 2b) from one fair quality RCT and one quasi-experimental study that aerobic exercise is not more effective than comparison interventions (relaxation, usual care) in reducing depression in patients with stroke.

Dexterity
Not effective
2b

One fair quality RCT (Nave et al., 2019) investigated the effect of aerobic exercise on dexterity in patients with stroke. This fair quality RCT randomized patients with acute/subacute stroke to receive aerobic physical fitness training using the PHYS-STROKE program or relaxation. Dexterity was measured by the Box and Block Test at post-treatment (4 weeks) and follow-up (3, 6 months). No significant between-group differences were found at any time points.

Conclusion: There is limited evidence (Level 2b) from one fair quality RCT that aerobic exercise is not more effective than a comparison intervention (relaxation) in improving dexterity in patients with stroke.

Executive functions
Not effective
2b

One fair quality RCT (Nave et al., 2019) investigated the effect of aerobic exercise on executive functions in patients with stroke. This fair quality RCT randomized patients with acute/subacute stroke to receive aerobic physical fitness training using the PHYS-STROKE program or relaxation. Executive functions were measured by the Trail Making Test (TMT – A, B) at post-treatment (4 weeks) and follow-up (3, 6 months) and the Regensburger Wort-Flüssigkeits-Test at follow-up (3 months). No significant between group differences were found on any of the measures at any time point.

Conclusion: There is limited evidence (Level 2b) from one fair quality RCT that aerobic exercise is not more effective than a comparison intervention (relaxation) in improving executive functions in patients with stroke.

Exercise capacity
Not effective
2b

One quasi-experimental design study (Marsden et al., 2016) investigated the effect of aerobic exercise on exercise capacity in patients with stroke. This quasi-experimental design study assigned patients with acute, subacute or chronic stroke to receive a home- and community-based exercise program with aerobic content or usual care. Exercise capacity was measured by the Shuttle Walk Test at post-treatment (12 weeks). No significant between-group difference was found.

Conclusion: There is limited evidence (Level 2b) from one quasi-experimental study that aerobic exercise is not more effective than a comparison intervention (usual care) in improving exercise capacity in patients with stroke.

Fatigue
Not effective
2b

One quasi-experimental design study (Marsden et al., 2016) investigated the effect of aerobic exercise on fatigue in patients with stroke. This quasi-experimental study assigned patients with acute, subacute or chronic stroke to receive a home- and community-based exercise program with aerobic content or usual care. Fatigue was measured by the Fatigue Assessment Scale at post-treatment (12 weeks). No significant between-group difference was found.

Conclusion: There is limited evidence (Level 2b) from one quasi-experimental study that aerobic exercise is not more effective than a comparison intervention (usual care) in reducing fatigue in patients with stroke.

Functional independence
Effective
1b

One high quality RCT (Wang et al., 2014) and one fair quality RCT (Nave et al., 2019) investigated the effect of aerobic exercise on functional independence in patients with stroke.

The high quality RCT (Wang et al., 2014) randomized patients with subacute/chronic stroke to receive low-intensity aerobic training or no training; both groups received conventional rehabilitation. Functional independence was measured by the Barthel Index at post-treatment (6 weeks). A significant between-group difference was found in favour of aerobic training vs. no training.

The fair quality RCT (Nave et al., 2019) randomized patients with acute/subacute stroke to receive aerobic physical fitness training using the PHYS-STROKE program or relaxation. Functional independence was measured by the Barthel Index (change scores) and the modified Rankin Scale at post-treatment (4 weeks) and follow-up (3, 6 months). No significant between-group differences were found at any time points.

Conclusion: There is moderate evidence (Level 1b) from one high quality RCT that aerobic exercise is more effective than no training in improving functional independence in patients with stroke.

Gait parameters
Not effective
2a

One fair quality RCT (Nave et al., 2019) investigated the effects of aerobic exercise in improving gait parameters in patients with stroke. This fair quality RCT randomized patients with acute/subacute stroke to receive aerobic physical fitness training using the PHYS-STROKE program or relaxation. gait parameters (Number of steps/day, Step length, Step Cadence, gait Energy Cost) were measured at post-treatment (4 weeks) and follow-up (3, 6 months). No significant between-group differences were found at any time points.

Conclusion: There is limited evidence (Level 2a) from one fair quality RCT that aerobic exercise is not more effective than a comparison intervention (relaxation) in improving gait parameters in patients with stroke.

Health-related quality of life
Effective
1b

One high quality RCT (Sandberg et al., 2016), one fair quality RCT (Nave et al., 2019) and one quasi-experimental design study (Marsden et al., 2016) investigated the effect of aerobic exercise on health-related quality of life (HRQoL) in patients with stroke.

The high quality RCT (Sandberg et al., 2016) randomized patients with acute/subacute stroke to receive an aerobic exercise program or no exercise program. HRQoL was measured by the European Quality of Life Scale (EQ-5D: Total score; Visual analogue Scale) at post-treatment (12 weeks). A significant between-group difference was found for one measure of HRQoL (EQ-5D: Visual analogue scale), favouring aerobic exercise program vs. no exercise program.

The fair quality RCT (Nave et al., 2019) randomized patients with acute/subacute stroke to receive aerobic physical fitness training using the PHYS-STROKE program or relaxation. HRQoL was measured by the EuroQoL Quality of Life Questionnaire 5D-5L at post-treatment (4 weeks) and follow-up (3, 6 months). No significant between-group differences were found at any time points.

The quasi-experimental study (Marsden et al., 2016) assigned patients with acute, subacute or chronic stroke to receive a home- and community-based exercise program with aerobic content or usual care. HRQoL was measured by the stroke and Aphasia Quality of Life-39 at post-treatment (12 weeks). No significant between-group difference was found.

Conclusion: There is moderate evidence (Level 1b) from one high quality RCT that aerobic exercise is more effective than a comparison intervention (no exercise program) in improving health-related quality of life in patients with stroke.

Mobility
Not effective
1b

One high quality RCT (Sandberg et al., 2016) and one fair quality RCT (Nave et al., 2019) investigated the effect of aerobic exercise on mobility in patients with stroke.

The high quality RCT (Sandberg et al., 2016) randomized patients with acute/subacute stroke to receive an aerobic exercise program or no exercise program. Mobility was measured by the Timed Up and Go test at post-treatment (12 weeks). A significant between-group difference was found, favouring aerobic exercise program vs. no exercise program.

The fair quality RCT (Nave et al., 2019) randomized patients with acute/subacute stroke to receive aerobic physical fitness training using the PHYS-STROKE program or relaxation. Mobility was measured by the Rivermead Mobility Index, Use of walking aids and Functional Ambulation Category, at post-treatment (4 weeks) and follow-up (3, 6 months). No significant between group differences were found on any of the measures at any time point.

Conclusion: There is moderate evidence (Level 1b) from one high quality RCT that aerobic exercise is more effective than a comparison intervention (no exercise program) in improving mobility in patients with stroke.

Motor function
Effective
1b

One high quality RCT (Wang et al., 2014) investigated the effect of aerobic exercise on motor function in patients with stroke. This high quality RCT randomized patients with subacute/chronic stroke to receive low-intensity aerobic training or no training; both groups received conventional rehabilitation. Motor function was measured by the Fugl Meyer Assessment (FMA: Total motor score) at post-treatment (6 weeks). A significant between-group difference was found, favouring aerobic exercise vs. no training.

Conclusion: There is moderate evidence (Level 1b) from one high quality RCT that aerobic exercise is more effective than no training (conventional rehabilitation alone) in improving motor function in patients with stroke.

Motor function - lower extremity
Effective
1b

One high quality RCT (Wang et al., 2014) investigated the effect of aerobic exercise on lower extremity motor function in patients with stroke. This high quality RCT randomized patients with subacute/chronic stroke to receive low-intensity aerobic training or no training; both groups received conventional rehabilitation. Lower extremity motor function was measured by the Fugl Meyer Assessment (FMA: Lower extremity score) at post-treatment (6 weeks). A significant between-group difference was found, favouring aerobic exercise vs. no training.

Conclusion: There is moderate evidence (Level 1b) from one high quality RCT that aerobic exercise is more effective than no training in improving lower extremity motor function in patients with stroke.

Motor function - upper extremity
Not effective
1b

One high quality RCT (Wang et al., 2014) and one fair quality RCT (Nave et al., 2019) investigated the effect of aerobic exercise on upper extremity motor function in patients with stroke.

The high quality RCT (Wang et al., 2014) randomized patients with subacute/chronic stroke to receive low-intensity aerobic training or no training; both groups received conventional rehabilitation. Upper extremity motor function was measured by the Fugl Meyer Assessment (FMA: Upper extremity score) at post-treatment (6 weeks). No significant between-group difference was found.

The fair quality RCT (Nave et al., 2019) randomized patients with acute/subacute stroke to receive aerobic physical fitness training using the PHYS-STROKE program or relaxation. Upper extremity motor function was measured by the Rivermead Mobility Index (RMI – arm score) at post-treatment (4 weeks) and follow-up (3, 6 months). A significant between-group differences was found at 6-month follow up only, favouring aerobic physical fitness training vs. relaxation.

Conclusion: There is moderate evidence (Level 1b) from one high quality RCT and one fair quality RCT that aerobic exercise is not more effective than comparison interventions (no training, relaxation) in improving upper extremity motor function in patients with stroke.

Muscle strength
Not effective
2b

One fair quality RCT (Nave et al., 2019) investigated the effect of aerobic exercise on muscle strength in patients with stroke. This fair quality RCT randomized patients with acute/subacute stroke to receive aerobic physical fitness training using the PHYS-STROKE program or relaxation. Muscle strength was measured by the Medical Research Council (MRC) Scale at post-treatment (4 weeks) and follow-up (3, 6 months). No significant between-group difference was found at any time points.

Conclusion: There is limited evidence (Level 2b) from one fair quality RCT that aerobic exercise is not more effective than a comparison intervention (relaxation) in improving muscle strength in patients with stroke.

Sleep quality
Not effective
2b

One fair quality RCT (Nave et al., 2019) investigated the effect of aerobic exercise on sleep quality in patients with stroke. This fair quality RCT randomized patients with acute/subacute stroke to receive aerobic physical fitness training using the PHYS-STROKE program or relaxation. Sleep quality was measured by the Pittsburgh Sleep Quality Score at post-treatment (4 weeks) and follow-up (3, 6 months). No significant between-group difference was found at any time point.

Conclusion: There is limited evidence (Level 2b) from one fair quality RCT that aerobic exercise is not more effective than a comparison intervention (relaxation) in improving sleep quality in patients with stroke.

Spasticity
Effective*
2b

One fair quality RCT (Nave et al., 2019) investigated the effect of aerobic exercise on spasticity in patients with stroke. This fair quality RCT randomized patients with acute/subacute stroke to receive aerobic physical fitness training using the PHYS-STROKE program or relaxation. spasticity was measured by the Resistance to Passive Movement Scale (REPAS) at post-treatment (4 weeks) and follow-up (3, 6 months). A significant between-group differences was found at follow up (6 months), favouring aerobic physical fitness training vs. relaxation.

Conclusion: There is limited evidence (Level 2b) from one fair quality RCT that aerobic exercise is more effective, in the long term*, than a comparison intervention (relaxation) in reducing spasticity in patients with stroke.

Stroke outcomes
Effective
1b

One high quality RCT (Sandberg et al., 2016) investigated the effect of aerobic exercise on stroke outcomes in patients with stroke. This high quality RCT randomized patients with acute/subacute stroke to receive an aerobic exercise program or no exercise program. stroke outcomes were measured by the stroke Impact Scale (SIS: Daily activities, Recovery) at post-treatment (12 weeks). A significant between-group difference was found in one measure (SIS: Recovery), favouring aerobic exercise program vs. no exercise.

Conclusion: There is moderate evidence (Level 1b) from one high quality RCT that aerobic exercise is more effective than a comparison intervention (usual care) in reducing some stroke outcomes in patients with stroke.

Walking endurance
Effective
1b

One high-quality RCT (Sandberg et al., 2016), one fair quality RCT (Nave et al., 2019) and one quasi-experimental study (Marsden et al., 2016) investigated the effect of aerobic exercise on walking endurance in patients with stroke.

The high quality RCT (Sandberg et al., 2016) randomized patients with acute/subacute stroke to receive an aerobic exercise program or no exercise program. Walking endurance was measured by the  6 Minute Walk Test (6MWT) at post-treatment (12 weeks). A significant between-group difference was found, favouring aerobic exercise vs. no exercise.

The fair quality RCT (Nave et al., 2019) randomized patients with acute/subacute stroke to receive aerobic physical fitness training using the PHYS-STROKE program or relaxation. Walking endurance was measured by the 6MWT at post-treatment (4 weeks) and follow-up (3, 6 months). No significant between-group difference was found at any time points.

The quasi-experimental study design (Marsden et al., 2016) assigned patients with acute, subacute or chronic stroke to receive a home- and community-based exercise program with aerobic content or usual care. Walking endurance was measured by the 6MWT at post-treatment (12 weeks). A significant between-group difference was found, favouring aerobic exercise vs. usual care.

Conclusion: There is moderate evidence (Level 1b) from one high quality RCT and one quasi-experimental study design that aerobic exercise is more effective than comparison interventions (no exercise, usual care) in improving walking endurance in patients with stroke.

Walking speed
Effective
1b

One high quality RCT (Sandberg et al., 2016), one fair quality RCT (Nave et al., 2019) and one quasi-experimental study design (Marsden et al., 2016) investigated the effect of aerobic exercise on walking speed in patients with stroke.

The high quality RCT (Sandberg et al., 2016) randomized patients with acute/subacute stroke to receive an aerobic exercise program or no exercise program. Walking speed was measured by the  10 Minute Walk Test (10MWT) at post-treatment (12 weeks). A significant between-group difference was found, favouring aerobic exercise vs. no exercise.

The fair quality RCT (Nave et al., 2019) randomized patients with acute/subacute stroke to receive aerobic physical fitness training using the PHYS-STROKE program or relaxation. Walking speed was measured by the 10MWT post-treatment (4 weeks) and follow-up (3, 6 months). No significant between group difference was found at any time point.

The quasi-experimental study design (Marsden et al., 2016) assigned patients with acute, subacute or chronic stroke to receive a home- and community-based exercise program with aerobic content or usual care. Walking speed was measured by the 10MWT (Fast, Self-selected speed) at post-treatment (12 weeks). No significant between-group difference was found.

Conclusion: There is moderate evidence (Level 1b) from one high quality RCT that aerobic exercise is more effective than no exercise in improving walking speed in patients with stroke.

References

Faulkner, J., McGonigal, G., Woolley, B., Stoner, L., Wong, L., & Lambrick, D. (2015). A randomized controlled trial to assess the psychosocial effects of early exercise engagement in patients diagnosed with transient ischaemic attack and mild, non-disabling stroke. Clinical Rehabilitation29(8), 783-794.
https://journals.sagepub.com/doi/full/10.1177/0269215514555729?casa_token=R7BB6cYVToAAAAAA%3AOFN0VReAB8HomN2EmpuqI_RFSUW4EvcKLEpYsPlH-wmXYfvkRVv3fL-L7f-bbXGIlcrcGYQHdXrLmA

Gordon, C. D., Wilks, R., & McCaw-Binns, A. (2013). Effect of aerobic exercise (walking) training on functional status and health-related quality of life in chronic stroke survivors: a randomized controlled trial. Stroke, 44(4), 1179-1181.
https://www.ahajournals.org/doi/full/10.1161/STROKEAHA.111.000642

Lee, Y. H., Park, S. H., Yoon, E. S., Lee, C. D., Wee, S. O., Fernhall, B., & Jae, S. Y. (2015). Effects of combined aerobic and resistance exercise on central arterial stiffness and gait velocity in patients with chronic poststroke hemiparesis. American Journal of Physical Medicine & Rehabilitation94(9), 687-695.
https://journals.lww.com/ajpmr/fulltext/2015/09000/Effects_of_Combined_Aerobic_and_Resistance.3.aspx?casa_token=KwoozWjzPWwAAAAA:qkb9LlDGH-rMj5lOOEvpd7zIkx7zeRoZgmXHDRIACPyqBOgU4lzzJnbDaTd87F5Hgoc3Ukow6jCBAOUuUKoCau7PqcY

Liu-Ambrose, T., & Eng, J. J. (2015). Exercise training and recreational activities to promote executive functions in chronic stroke: a proof-of-concept study. Journal of Stroke and Cerebrovascular Diseases24(1), 130-137.
https://www.sciencedirect.com/science/article/abs/pii/S1052305714004169

Lund, C., Dalgas, U., Grønborg, T. K., Andersen, H., Severinsen, K., Riemenschneider, M., & Overgaard, K. (2018). Balance and walking performance are improved after resistance and aerobic training in persons with chronic stroke. Disability and rehabilitation, 40(20), 2408-2415.
https://www.tandfonline.com/doi/full/10.1080/09638288.2017.1336646?casa_token=-jl-IeFq0cwAAAAA%3AFp7OwEr3QabrfxNE9vWV4w6NJZFNrK0FFaoIFN6uRh9WuxC3_YIl2tvN7OYH7mid3DsUqUYcqVDZJQ

Marsden, D. L., Dunn, A., Callister, R., McElduff, P., Levi, C. R., & Spratt, N. J. (2016). A home-and community-based physical activity program can improve the cardiorespiratory fitness and walking capacity of stroke survivors. Journal of Stroke and Cerebrovascular Diseases, 25(10), 2386-2398.
https://www.sciencedirect.com/science/article/pii/S1052305716301240?casa_token=OTKqoIi5B6oAAAAA:wgMBHD1qRkcQTDIIAdW8kfzhih_3r343EUI_I3TE37wXRVSX_p3-kRPuNC3_Feh0vplp63m0bNg

Moore, S. A., Hallsworth, K., Jakovljevic, D. G., Blamire, A. M., He, J., Ford, G. A., … & Trenell, M. I. (2015). Effects of community exercise therapy on metabolic, brain, physical, and cognitive function following stroke: a randomized controlled pilot trial. Neurorehabilitation and neural repair, 29(7), 623-635.
https://journals.sagepub.com/doi/full/10.1177/1545968314562116

Morén, C., Welmer, A. K., Hagströmer, M., Karlsson, E., & Sommerfeld, D. K. (2016). The effects of “physical activity on prescription” in persons with transient ischemic attack: a randomized controlled study. Journal of Neurologic Physical Therapy40(3), 176-183.
https://www.ingentaconnect.com/content/wk/npt/2016/00000040/00000003/art00003

Nave, A. H., Rackoll, T., Grittner, U., Bläsing, H., Gorsler, A., Nabavi, D. G., … & Flöel, A. (2019). Physical Fitness Training in Patients with Subacute Stroke (PHYS-STROKE): multicentre, randomised controlled, endpoint blinded trial. BMJ, 366.
https://www.bmj.com/content/366/bmj.l5101.long

Pang, M. Y., Eng, J. J., Dawson, A. S., McKay, H. A., & Harris, J. E. (2005). A community‐based fitness and mobility exercise program for older adults with chronic stroke: A randomized, controlled trial. Journal of the American Geriatrics Society, 53(10), 1667-1674.
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Sandberg, K., Kleist, M., Falk, L., & Enthoven, P. (2016). Effects of twice-weekly intense aerobic exercise in early subacute stroke: a randomized controlled trial. Archives of physical medicine and rehabilitation, 97(8), 1244-1253.
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Severinsen, K., Jakobsen, J. K., Pedersen, A. R., Overgaard, K., & Andersen, H. (2014). Effects of resistance training and aerobic training on ambulation in chronic stroke. American journal of physical medicine & rehabilitation, 93(1), 29-42.
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Shaughnessy, M., Michael, K., & Resnick, B. (2012). Impact of treadmill exercise on efficacy expectations, physical activity, and stroke recovery. The Journal of neuroscience nursing: journal of the American Association of Neuroscience Nurses, 44(1), 27.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249605/

Tang, A., Eng, J. J., Krassioukov, A. V., Madden, K. M., Mohammadi, A., Tsang, M. Y., & Tsang, T. S. (2014). Exercise-induced changes in cardiovascular function after stroke: a randomized controlled trial. International Journal of Stroke, 9(7), 883-889.
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Tang, A., Eng, J. J., Tsang, T. S., & Liu-Ambrose, T. (2016). High-and low-intensity exercise do not improve cognitive function after stroke: A randomized controlled trial. Journal of rehabilitation medicine, 48(10), 841-846.
https://www.ingentaconnect.com/contentone/mjl/sreh/2016/00000048/00000010/art00002

Wijkman, M. O., Sandberg, K., Kleist, M., Falk, L., & Enthoven, P. (2018). The exaggerated blood pressure response to exercise in the sub‐acute phase after stroke is not affected by aerobic exercise. The Journal of Clinical Hypertension20(1), 56-64.
https://onlinelibrary.wiley.com/doi/full/10.1111/jch.13157

Wang, Z., Wang, L., Fan, H., Lu, X., & Wang, T. (2014). Effect of low-intensity ergometer aerobic training on glucose tolerance in severely impaired nondiabetic stroke patients. Journal of Stroke and Cerebrovascular Diseases, 23(3), e187-e193.
https://www.sciencedirect.com/science/article/pii/S1052305713003959?casa_token=GoBcYRstDJ8AAAAA:IJo9a1F9CwFK_YLGBHuYDi0q-ca7d6CUdht3OvsR6hI-MgDQIxyJV2khbzTwrKl5f4bSVQZR1N4

Excluded studies:

Bo, W., Lei, M., Tao, S., Jie, L. T., Qian, L., Lin, F. Q., & Ping, W. X. (2019). Effects of combined intervention of physical exercise and cognitive training on cognitive function in stroke survivors with vascular cognitive impairment: a randomized controlled trial. Clinical Rehabilitation, 33(1), 54-63.
Reason for exclusion: The main part of the treatment focused on endurance, strength and balance (30-35 minutes) and aerobic exercise was provided only for the first 5 minutes as warm-up (cycling, jogging).

Jin, H., Jiang, Y., Wei, Q., Chen, L., & Ma, G. (2013). Effects of aerobic cycling training on cardiovascular fitness and heart rate recovery in patients with chronic stroke. NeuroRehabilitation32(2), 327-335.
Reason for exclusion: Included in treadmill module.

Jin, H., Jiang, Y., Wei, Q., Wang, B., & Ma, G. (2012). Intensive aerobic cycling training with lower limb weights in Chinese patients with chronic stroke: discordance between improved cardiovascular fitness and walking ability. Disability and Rehabilitation34(19), 1665-1671.
Reason for exclusion: Included in treadmill module.

Balance Training

Evidence Reviewed as of before: 09-06-2012
Author(s)*: Annabel McDermott, OT; Nicol Korner-Bitensky, PhD OT; Norine Foley, BASc; Mark Speechley, PhD; Nancy M. Salbach, PhD, PT; Maxim Ben Yakov, BSc. PT; Robert Teasell, MD
Patient/Family Information Table of contents

Introduction

Balance problems are caused by motor, sensory and cognitive impairments and are one of the most common issues after stroke. Impaired postural control contributes to difficulties with recovery of mobility and functional independence among patients with stroke. Most rehabilitation therapies aim for the restoration of balance in sitting, as well as in standing, reaching, and rising to stand.

Additional support from undergraduate students, School of Physical and Occupational Therapy, McGill University: Natasha Alloul, Julie Parent -Taillon, Nadia Boule-Laghzali, Genevieve Larivee, Ang Li, Zahra Adl-Zarabi, Michael Dyck

Patient/Family Information

Author: Maxim Ben Yakov, BSc. PT

What is balance training?

To sit and to walk safely you need to have good balance. Balance training focuses on practicing and improving the body’s ability to perform coordinated movement (of arms and legs) while maintaining a balanced posture, i.e. without falling, stumbling, or feeling wobbly. This is usually achieved through rehearsal of tasks, such as reaching for objects while holding the body straight. Training in sitting and standing should be initiated as soon as possible after a stroke, as these are basic, necessary tasks in daily life.

Why train balance after a stroke?

Balance is a basic requirement for active, independent, and safe movement of our bodies in daily life. Before your stroke, you probably balanced your body when sitting and standing automatically, without thinking about it. After a stroke, you may have balance problems that require you to concentrate a great deal to do simple things, such as putting on your socks, or standing at a sink to brush your teeth. Even people who experience only small problems with balance may have difficulty when walking outside on uneven ground or when crossing the street.

Are there different kinds of balance training?

Yes, there are different ways to retrain balance after a stroke.

  • Functional balance training: Recently, balance training has been focusing more on functional, task-specific training. In functional training, the individual who has had a stroke works on typical tasks that people perform in their daily lives, such as reaching into a cupboard for a cup or plate, or trying to carry a grocery bag.
  • Body weight support: After a stroke, some individuals are too weak and have difficulty sitting, standing, or walking in therapy. If this is the case, your body weight may be supported while you stand or walk either  by your therapist or by a body harness.
  • Hydrotherapy: Sometimes, balance training is done in a therapeutic pool, using a technique called Hydrotherapy. Water makes your limbs lighter, since you are not moving against gravity. Water also provides support and stimulation so that you can work on your balance in a safe environment. Your therapist will usually work in the water with you to make sure that you are well supported and safe.
  • Proprioception training: Balance training can also include something called proprioception training, which can help you to be aware of where your arms and legs are in space. For example, after a stroke some people have difficulty knowing where their hand is when their eyes are closed. Proprioception is important to achieve proper balance, and the good news is that as we work on improving balance, we are training proprioception as well.Other types of balance training you might hear about are:
  • “Bobath approach”: Bobath was a physiotherapist who developed a treatment approach that analyzes and interprets how you move after your stroke. After a stroke, many people move in a way that is different from before. Your therapist will work on training and modifying your movements to help you accomplish daily tasks. Usually a therapist will guide your arms, legs or trunk through the correct movements so that you can re-learn to do the activities correctly.
  • “Visual feedback” or “Biofeedback for trunk control”: This technique uses a mirror in front of you or a video camera system to track your body, arms, or legs while doing activities like catching a ball or placing objects on a shelf. This allows you to see how you are moving so that you can try to correct your movements.
  • “Vision-deprived training”: With your eyes covered, your therapist will help you do activities like standing on one or both legs, trying to sit on a pillow, or simply getting up from a chair and sitting down. This challenges your balance more than when your eyes are open. This is an activity you should try doing as you get better.
  • “Independent practice”: You can work on your balance on your own. For example, during your independent exercise, you could have as a goal to stand on both legs with equal weight, or to try and sit on both buttocks with equal pressure.
    NOTE: You should only try this once your therapist tells you that it is safe for you to do so.
  • “Balance biofeedback”: After a stroke, it is typical to put more weight on your “good” leg when you are standing. However, it is important that you also put weight on your weaker leg. While you are standing, your therapist will use a computer screen with a special mat that will sense how much pressure goes through each foot. The amount of weight put through your weaker leg will then be recorded and will show up on the computer screen. Training in this way gives you immediate feedback about how well you are doing. At first, the goal may be to increase the amount of weight you put on your weaker leg. Next, it may be to put an equal amount of weight on both legs while standing. Eventually, you may try to put more weight on your weaker leg. This is important because as we walk, we need to put our body weight through one leg at a time.
  • “Perceptual training”: This technique focuses on training the awareness of your arms, legs, and trunk in space. For example you might be asked to touch your knee and then your forehead while your eyes are closed.
  • “Multisensorial Training”: Following a stroke, you may become overly reliant on visual cues to help maintain your balance. Multisensorial training is a form of rehabilitation conducted while restricting the amount that you see. It focuses on the amount and intensity of your movements and exercise without placing emphasis on how well you perform them.

Does balance training work after a stroke?

Researchers have done experiments to see if balance training helps people who have had a stroke.

  • Task-oriented interventions: One high quality study looked at task-oriented interventions for walking. The results showed that this treatment can improve a person’s confidence in balance.
  • Perceptual exercises: After a stroke, it is common to have more body sway, and this makes you more unsteady on your feet. In one high quality study, results showed that perceptual exercises reduced the amount of body sway.
    NOTE: Even without a stroke, everyone has a certain normal amount of body sway that we are not aware of.
  • Bobath Therapy Approach: One high quality study showed that the Bobath approach did not improve independence in normal daily living, sitting balance, standing balance, or the amount of weight put on the weaker leg.
  • Task-specific reaching training: One high quality study found that task-specific reaching does not improve how evenly you distribute your body weight through both buttocks when sitting. The same study results showed that such training does not improve how equally you put your body weight through both feet while standing.
  • Independent-practice training: There is limited research from one fair quality study that showed that when independent-practice training is combined with therapy based on the Bobath approach it does not improve balance after a stroke.
  • Visual feedback training: There is limited research based on two fair quality studies suggesting that visual feedback training does not result in improvements in balance. It is worth noting that one study did find important gains in the ability to perform self-care activities (such as washing, toileting, dressing, and grooming).
  • Balance biofeedback training: There are conflicting findings in this area. Three fair quality studies found no real gains in balance after using this training method. In contrast, two high quality studies on balance biofeedback training found that balance did improve after a stroke. Another high quality study demonstrated that biofeedback for trunk control training can improve significantly standing balance (not when walking or reaching).
  • Multisensorial Training: One high quality study found that multisensorial training (a form of therapy conducted while restricting what you see and focusing on the amount and intensity of movement and exercise) is not more effective than neurodevelopmental therapy (a form of therapy which focuses on quality of movement and exercise) in improving standing balance. However, it is more effective at improving your balance when walking and moving around, as well as increasing independence in functional activities and improving quality of life.

Side effects/risks?

Balance is important to prevent you from falling. During balance training, you should always be supervised by an individual who knows about practicing balance training safely. Eventually, you will probably begin practicing balance exercises with your family or friends. Before you do so, your therapist should show them safe ways of working with you.

Who provides the treatment?

Balance training should be performed or supervised by a trained health professional. A variety of health professionals provide balance training as part of their treatment, including occupational therapists, physical therapists, and exercise therapists.

Clinician Information

Note: When reviewing the findings, it is important to note that they are always made according to randomized clinical trial (RCT) criteria – specifically as compared to a control group. To clarify, if a treatment is “effective” it implies that it is more effective than the control treatment to which it was compared. Non-randomized studies are no longer included when there is sufficient research to indicate strong evidence (level 1a) for an outcome.

Of the 42 studies included in this module that have investigated interventions to improve balance post-stroke, 25 are high quality randomized controlled trials. Interventions reviewed in this module include aquatic therapy, Bobath therapy, force platform or mechanical balance training devices, multisensory training, perceptual exercises, task-specific exercises, trunk exercises, vibration therapy and virtual reality. Although a majority of the studies demonstrated a positive benefit of balance training, the heterogeneity of intervention and outcomes measures does not allow us to make definite conclusions regarding any one most efficacious intervention method for balance re-training post-stroke.

Lubetzky-Vilnai & Kartin (2010) conducted a systematic review of recent studies on balance training interventions that comprised 22 RCTs, pilot studies and case series from January 2006 to February 2010. Comparison among studies was limited by diversity in balance training interventions (type, duration, intensity and progression), control interventions (conventional physiotherapy, standard interdisciplinary care, conventional gait training, patient-initiated training, body-weight supported training, standard rehabilitation and neurodevelopmental treatment) and outcomes measured. Most studies reported that balance training programs were not more effective than control therapies as both experimental and control groups demonstrated improved balance following intervention.

An & Shaughnessy (2011) conducted a systematic review of exercise interventions used to improve balance and/or gait following stroke. The authors reviewed 17 English-language RCTs published from 2001 to January 2010, 10 of which included balance as an outcome (5 of these were also included in the 2010 systematic review by Lubetzky-Vilnai & Kartin). This systematic review concluded that multisensory programs do not seem to be effective in improving balance following stroke. However, early initiation of exercise after stroke was reported to be effective in improving balance, and aerobic exercise was positively associated with improved balance in subacute and chronic stroke. The systematic review concluded that exercise performed for at least 20-60 minutes, 3-4 times a week for 6-12 weeks can improve balance following stroke.

Results Table

View results table

Outcomes

Aquatic therapy
Effective
2A

One fair quality RCT (Noh et al., 2008) has investigated the effectiveness of aquatic therapy in improving balance in patients with stroke.

The fair quality RCT (Noh et al., 2008) randomized patients with chronic stroke and unilateral limb weakness to an aquatic therapy program or a conventional gym exercise program. At one month post-treatment there were significant between-group differences, with those in the aquatic group having better balance (Berg Balance Scale) and weight-bearing ability on the affected side (vertical ground reaction force during forward and backward weight-shift). There was no significant group difference in weight-bearing ability during sit-to-stand or lateral weight-shift.

Conclusion: There is limited evidence (level 2a) from 1 fair quality RCT that aquatic therapy is more effective than a gym exercise program for improving balance, forward/backward weight shift and knee flexor strength of the affected limb in patients with stroke.

Note: however, the fair quality RCT found no significant difference between groups in weight shift during lateral movements and when rising from a chair, or strength of knee extensor and trunk muscles.

Bobath therapy
Effective
2a

One fair quality RCT (Mudie et al., 2002) has investigated the use of the Bobath approach in improving balance following stroke.

The fair quality study (Mudie et al., 2002) randomly assigned patients with acute stroke to one of four treatment groups: (1) task-specific reaching; (2) Bobath therapy interventions; (3) BPM biofeedback interventions; or (4) conventional physiotherapy and occupational therapy (control). The Bobath group demonstrated a significant improvement in seated symmetry of weight distribution at post-treatment (2 weeks), although results did not remain significant at follow-up time point (12 weeks). At 12 weeks post-study 29% of the Bobath group were able to distribute weight to both sides, in comparison to the BPM group (83%), task-specific group (38%) and the control group (0%).

Conclusion: There is limited evidence (level 2a) from 1 fair quality RCT that Bobath therapy is effective for improving balance (seated weight distribution) following stroke. However, between-group differences were not reported.

Cycling training
Effective
1B

One high quality RCT (Katz-Leurer et al., 2006) has investigated the effectiveness of cycling training in improving balance in patients with stroke.

The high quality RCT (Katz-Leurer et al., 2006) randomized patients with subacute stroke to receive cycling training and conventional rehabilitation or conventional rehabilitation training alone. At post-treatment (6 weeks) there were significant group-time interactions in favour of the cycling group compared to the control group for balance on the Postural Assessment Scale for stroke Patients total, static and dynamic scores. However, no significant between-group differences were seen for standing balance as measured using the Standing Balance Test.

Conclusion: There is moderate evidence (level 1b) from 1 high quality RCT that cycling training is more effective than conventional rehabilitation alone for improving balance in patients with stroke.

Note: However, the high quality RCT showed no significant between-group differences on the Standing Balance test.

Force platform training
Effective
1a

Two high quality RCTs (Sackley & Lincoln, 1997; Cheng et al., 2001), 6 fair quality RCTs (Shumway-Cook et al., 1988;Wong et al., 1997; Grant et al., 1997; Walker et al., 2000; Chen et al., 2002; Mudie et al., 2002) and 1 poor quality RCT (Geiger et al., 2001) have investigated the effect of force platform biofeedback training on balance following stroke.

The first high quality RCT (Sackley & Lincoln, 1997) randomized patients with subacute or chronic stroke to receive balance training using the Nottingham Balance Platform with visual feedback regarding weight distribution and weight shift activity, or a placebo balance intervention. Balance measures were taken at baseline, 4 weeks (post-treatment) and 12 weeks (follow-up) using assessment of stance symmetry and sway. Significant between-group differences were seen in favour of the treatment group compared to the placebo group for stance symmetry at post-treatment, but these differences did not remain significant at follow-up. There were no significant differences in sway.

The second high quality RCT (Cheng et al., 2001) assigned patients with hemiplegia following stroke to balance training using a dual force platform standing biofeedback trainer with visual and auditory feedback, or conventional physical therapy. Significant between-group differences were noted in favour of the force platform group compared to the control group on balance measures of mediolateral sway, rate of rise in force when rising from a chair, and frequency of falls post-stroke. There were no significant between-group differences in sit-to-stand or stand-to-sit performance at post-treatment, but at 6-month follow-up a significant difference in sit-to-stand performance was reported in favour of the force platform group compared to the control group.

The first fair quality RCT (Shumway-Cook et al., 1988) randomly assigned individuals with subacute stroke to standing balance retraining using a static force platform biofeedback device, or standing balance training without biofeedback. A significant between-group difference in lateral sway displacement was reported in favour of the force platform group compared to the control group. There was no significant difference in total sway area between groups.

The second fair quality RCT (Wong et al., 1997) randomised patients with acute stroke to training using a Standing Biofeedback Training (SBT) device that provides real-time visual and auditory weight bearing biofeedback, or a Standing Training Table (STT) worktable. Significant between-group differences in postural symmetry were seen at week 1, week 2 and week 4, in favour of the SBT group compared to the STT group. Note: significant between-group differences in postural symmetry were not seen at day 1 or week 3.

The third fair quality RCT (Grant et al., 1997) reported preliminary findings from a study by Walker et al., 2000 (see below), whereby 16 patients with stroke were randomly assigned to visual biofeedback balance training and physiotherapy, or standard balance training and physiotherapy. No significant differences were noted on measures of balance (Berg Balance Scale, postural sway, standing symmetry).

The fourth fair quality RCT (Walker et al., 2000) randomly assigned 54 patients with stroke to one of three treatment groups: (1) balance training using the dual force platform Balance Master with visual feedback and conventional physiotherapy and occupational therapy; (2) ‘standard’ balance training and conventional physiotherapy and occupational therapy; or (3) conventional physiotherapy and occupational therapy alone. There were no significant differences on measures of balance (Berg Balance Scale, postural sway) when comparing either intervention group with the control group.

The fifth fair quality RCT (Chen et al., 2002) randomly assigned patients with stroke to balance training using the Smart Balance Master with visual feedback in combination with conventional physical and occupational therapy, or physical and occupational therapy alone. Significant differences were observed between groups on one of three measures of static balance (absence of sway but not maximum stability or center of gravity alignment) and all three measures of dynamic balance (axis velocity, directional control, end-point excursion).

The sixth fair quality RCT (Mudie et al., 2002) randomly assigned individuals with recent stroke to one of four treatment groups: (1) task-specific reaching; (2) Bobath therapy interventions; (3) Balance Performance Monitor (BPM) weight-distribution training in sitting and standing with visual feedback; or (4) conventional physiotherapy and occupational therapy (control). The BPM group demonstrated a significant improvement in seated symmetry of weight distribution at post-treatment (2 weeks) but these results did not remain significant at follow-up time points (4 weeks, 12 weeks). At 12 weeks post-study 83% of the BPM group was distributing weight to both sides, as compared to 38% of the task-specific reaching group, 29% of the Bobath group and 0% of the control group. The BPM group also demonstrated some generalization of symmetry training in sitting to standing.

The poor quality study (Geiger et al., 2001) assigned patients with stroke to balance training using the forceplate Neurocom Balance Master with visual feedback, or regular balance training. There were no significant differences in balance (Berg Balance Scale) at post-treatment (4 weeks).

Conclusion: There is strong evidence (level 1a) from 2 high quality RCTs and 3 fair quality RCTs that force platform biofeedback training is more effective than control therapies for improving balance (e.g. symmetry, mediolateral sway, dynamic balance, frequency of falls) following stroke.

Note: However, numerous studies reported that force platform biofeedback training was not more effective than control therapies for improving other measures of balance (e.g. Berg Balance Scale, postural sway, seated weight-distribution).

Independent practice
Not Effective
2A

One fair quality RCT (Pollock et al. 2002) has investigated the efficacy of independent-practice training for improving balance post-stroke.

The fair quality RCT (Pollock et al. 2002) randomly assigned patient with stroke to 1 of 2 treatment groups: (1) Independent practice with balance-focused exercise in combination with conventional therapy; or (2) conventional therapy alone (control). No significant difference was found between groups. It was concluded that performance of postural control and weight distribution did not increase for individuals in either group post-stroke.

Conclusion: There is limited evidence (level 2a) from 1 fair quality study that independent-practice training with conventional therapy is not more effective than conventional therapy alone for improving balance post-stroke.

Mechanical balance training devices
Not Effective
1b

One high quality RCT (Goljar et al., 2010) and one controlled clinical trial (Byun et al., 2011) have investigated the effect of a mechanical balance training device on balance in patients with stroke.

The high quality RCT (Goljar et al., 2010) randomized patients with subacute or chronic stroke to receive physiotherapy and balance training using a mechanical device, or physiotherapy and conventional balance training. There was no significant between-group difference in balance (Berg Balance Scale; one-leg standing) at post-treatment.

The controlled clinical trial (non-randomized crossover design) (Byun et al., 2011) divided patients with chronic stroke into two groups to receive conventional rehabilitation in addition to balance training using a sliding rehabilitation machine for 2 weeks (experimental period), preceded (group B) or followed (group A) by 2 weeks of conventional rehabilitation alone (control period). There was a significant difference in favour of the experimental period as compared to the control period in improving balance (Berg Balance Scale).

Conclusion: There is moderate evidence (level 1b) from 1 high quality RCT that a mechanical balance training device is not more effective than physiotherapy and conventional training for improving balance among patients with subacute and chronic stroke.

Note: However, 1 controlled clinical trial found that a balance trainer (sliding rehabilitation machine) is more effective than conventional rehabilitation alone in improving balance among patients with chronic stroke. Variations in the type of mechanical balance training devices used may account for differences in results between studies.

Multisensory training
Effective
1B

Two high quality RCTs (Yelnik et al., 2008; Gok et al., 2008), one fair quality RCT (Bayouk et al., 2006) and one poor quality RCT(Onigbinde et al., 2009) have investigated the use of multisensorial training on balance in patients with stroke.

The first high quality RCT (Yelnik et al., 2008) randomised patients with subacute and chronic stroke to receive multisensorial therapy or neurodevelopmental therapy (control group). No significant between-group differences in balance (Berg Balance Scale*; self reported perception of security) were seen at post treatment (30 days) or follow-up (60 days). However, a significant between-group difference in dynamic balance (percentage of double-limb stance time) was seen at follow-up, in favour of the multisensorial group compared to the control group.

*Note: Differences in standing balance may not have been detected due to the ceiling effect of the Berg Balance Scale. The authors also questioned the clinical meaning of the improvements to the patients due to the small values.

The second high quality RCT (Gok et al., 2008) randomized patients with chronic stroke to receive balance training using a kinaesthetic ability training (KAT) device and conventional rehabilitation, or conventional rehabilitation alone. The KAT device held a centrally-pivoted balance platform with a pressure bladder that allowed adjustments in weight shift in response to visual feedback. At 4 weeks (post-treatment) the KAT group showed significantly greater improvement in balance (Fugl-Meyer stroke Assessment [FMA] balance subscore; KAT static and dynamic balance indices) than the control group.

The fair quality RCT (Bayouk et al., 2006) randomised hemiparetic patients with chronic stroke to a task-oriented exercise program with manipulation of sensory input (eyes open/closed; soft/firm surface) or a task-oriented program under normal conditions. Outcomes were taken as a measure of the center of pressure (COP) displacement during double-legged stance and sit-to-stand with eyes open or closed and on normal or soft surfaces, as well as the 10-m walking test. Although between-group differences were not reported*, a significant difference in pre- and post-test balance (COP displacement during double-leg stance with eyes open on normal and soft surfaces) was seen for the experimental group but not the control group. Both groups demonstrated a significant difference in pre- and post-test results in other balance measures (COP displacement during sit-to-stand with eyes open on a soft surface) and walking speed (10-m walking test).

*Note: as between-group differences are not reported, this study is not used to determine level of evidence regarding the effectiveness of multisensorial training in the conclusion below.

The poor quality RCT (Onigbinde et al., 2009) randomised patients with stroke (time since stroke not specified) to perform wobble board exercises with visual feedback and conventional physiotherapy, or conventional physiotherapy alone. At post-treatment (6 weeks) there were significant between-group differences in static balance (eyes closed) and dynamic balance (Four Square Step Test time), in favour of the experimental group compared to the control group. There were no significant between-group differences in static balance (eyes open) at post-treatment.

Conclusion: There is moderate evidence (level 1b) from 1 high quality RCT and 1 poor quality RCT that multisensorial training is more effective than conventional rehabilitation for improving balance following stroke. One fair quality RCT also reported a significant improvement in balance following multisensory training.

Note: One high quality RCT reported no significant difference in balance between multisensory training and conventional rehabilitation, although noted a potential ceiling effect of the instrument used to measure balance (Berg Balance Scale). The same RCT saw a significant between-group difference in dynamic balance at follow-up (but not at post-treatment), in favour of the multisensorial training group.

Perceptual exercises
Effective
1B

One high quality RCT (Morioka et al. 2003) has investigated the use of perceptual training for balance retraining post-stroke.

The high quality RCT (Morioka et al., 2003) randomly assigned patients with stroke to receive rehabilitation including perceptual learning exercises or standard rehabilitation (control). Significant improvements were reported in the length, the enveloped area and the rectangular area of the parameter of postural sway in the group receiving the perceptual exercises compared to the control group.

Conclusion: There is moderate evidence (level 1b) from 1 high quality RCT that perceptual exercises are more effective than standard rehabilitation for improving balance measures post-stroke.

Speed-dependent treadmill training
Not Effective
1B

One high quality RCT (Lau et al., 2011) has investigated the use of speed-dependent treadmill training for improving balance following stroke.

The high quality RCT (Lau et al., 2011) randomised patients with subacute stroke to a speed-dependent treadmill training group or a steady-speed treadmill training group. At post-treatment (10 x 30-minute sessions) there was no significant between-group difference in balance (Berg Balance Scale).

Conclusion: There is moderate evidence (level 1b) from 1 high quality RCT that speed-dependent treadmill training is not more effective than steady-speed treadmill training for improving balance following stroke.

Standing practice
Not Effective
1b

One high quality RCT (Allison & Dennett, 2007) has investigated the effectiveness of standing practice to improve balance among patients with stroke.

The high quality RCT (Allison & Dennett, 2007) randomized patients with acute or subacute stroke to receive standing practice and conventional physiotherapy or physiotherapy alone. There were no significant between-group differences in balance or trunk control (Berg Balance Scale; Trunk Control Test; Rivermead Motor Assessment – Gross Functional Tool Section) at weeks 1, 2 or 12.

Note: However, a significant difference in change in Berg Balance Scale scores from week 1 to week 12 was seen in favour of the standing practice group compared to the control group.

Conclusion: There is moderate evidence (level 1b) from 1 high quality RCT that standing practice is not more effective than conventional physiotherapy alone for improving balance and trunk control in patients with acute or subacute stroke.

Tai chi
Effective
1B

One high quality RCT (Au-Yeung et al., 2009) has investigated the effect of tai chi on balance in patients with stroke.

The high quality RCT (Au-Yeung et al., 2009) randomized patients with chronic stroke to a tai chi group or a control group that performed general exercises for breathing, stretching, mobilization, memory and reasoning. Dynamic standing balance was measured by center of gravity (COG) excursion during self-initiated body leaning forward, backward and towards the affected and non-affected sides using the Limit of Stability test; and standing equilibrium was measured by the Sensory Organization test. A significant between-group difference was seen in COG excursion amplitude when leaning forward, backward and toward the nonaffected side from week 6 (mid-treatment), and also toward the affected side from week 12 (post-treatment), in favour of the tai chi group compared to the control group. These results were maintained at 18 weeks (follow-up). A significant between-group difference in reaction time during voluntary weight shift towards the non-affected side was seen at 12 weeks and 18 weeks in favour of the tai chi group compared to the control group. There was a significant difference in standing equilibrium with vestibular input at 12 weeks (post-treatment), in favour of the tai chi group compared to the control group.

Conclusion: There is moderate evidence (level 1b) from 1 high quality RCT that tai chi is more effective than regular exercises for improving balance in patients with chronic stroke.

Task-oriented walking
Not Effective
1A

Five high quality RCTs (Richards et al., 1993; McClellan & Ada, 2004; Salbach et al., 2004 and Salbach et al., 2005; Marigold et al., 2005; Outermans et al., 2010), 1 fair quality RCT (Dean et al., 2000) and 1 quasi-experimental study (Rose et al., 2011) have investigated the use of task-oriented interventions targeting walking for balance retraining post-stroke.

The first high quality RCT (Richards et al., 1993) randomised patients with acute stroke to receive intensive gait-focused task-oriented physical therapy, or one of two control groups that received different intensities of standard physical therapy. No significant difference in balance (Berg Balance Scale, Fugl Meyer Assessment balance subscale) was seen between groups at 6 weeks (post-treatment) or 3 months (follow-up).

The second high quality RCT (McClellan & Ada, 2004) randomised patients with chronic stroke to receive home-based task-oriented mobility training or home-based task-oriented upper extremity training exercises. There was a significant between-group difference in standing balance (Functional Reach Test) at 6 weeks (post-treatment) and at 2-month follow-up, in favour of the task-oriented mobility group compared to the task-oriented upper extremity group.

The third high quality RCT (Salbach et al., 2004; Salbach et al., 2005) randomised patients with subacute or chronic stroke to receive task-oriented mobility training or task-oriented upper extremity training. There was a significant between-group difference in balance confidence (Activities-specific Balance Confidence scale), but not balance (Berg Balance Scale) at 6 weeks (post-treatment), in favour of the task-oriented mobility group compared to the task-oriented upper extremity group.

The fourth high quality RCT (Marigold et al., 2005) randomised patients with chronic stroke to receive a task-oriented mobility training program or a program that emphasized slow stretching and weight-shift. No significant differences in balance (Berg Balance Scale), balance confidence (Activities-specific Balance Confidence Scale) or falls (unforced falls during reaching transferring; induced falls during platform translation) were seen at 10 weeks (post-treatment) or 1-month follow-up.

The fifth high quality RCT (Outermans et al., 2010) randomised patients with subacute stroke to receive high intensity task-oriented mobility training or low intensity standard therapy. No significant between-group differences in balance (Berg Balance Test; Functional Reach Test) were seen at 4 weeks (post-treatment).

The fair quality RCT (Dean et al., 2000) randomised patients with chronic stroke and residual hemiplegia to receive task-oriented mobility training or task-oriented upper extremity training. A significant between-group difference in balance during stepping (Step Test) was seen in favour of the task-oriented mobility group compared to the upper extremity group at 4 weeks (post-treatment) and 2 months (follow-up).

The quasi-experimental study (Rose et al., 2011) assigned patients with acute stroke to receive task-oriented mobility training or conventional rehabilitation. No significant between-group difference in balance (Berg Balance Scale) was seen at hospital discharge (post-treatment).

Conclusion 1 (balance): There is strong evidence (level 1a) from 4 high quality RCTs and 1 quasi-experimental study that task-oriented mobility training is not more effective than control therapies (conventional rehabilitation, physiotherapy) for improving balance following stroke.

Note: however, 1 high quality RCT found a significant difference in standing balance, and 1 fair quality RCT found a significant difference in stepping balance, in favour of task-oriented mobility training compared to control therapies.

Conclusion 2 (balance confidence): There is conflicting evidence (level 4) between 2 high quality RCTs regarding the effectiveness of task-oriented mobility training for improving balance confidence following stroke.

One fair quality RCT (Mudie et al. 2002) has investigated the use of task-specific reaching for balance retraining post-stroke.

The fair quality RCT (Mudie et al., 2002) randomly assigned patients with recent stroke to one of four treatment groups: (1) task-specific reaching; (2) Bobath therapy interventions; (3) BPM biofeedback interventions; or (4) conventional physiotherapy and occupational therapy (control). The task-specific reaching group did not demonstrate a significant improvement in seated weight distribution at post-treatment (2 weeks) or follow-up time points (4 weeks, 12 weeks), whereas all other groups demonstrated significantly improved sitting symmetry at post-treatment. At 12 weeks post-study, 38% of the task-specific reaching group were distributing weight to both sides, as compared to 83% of the BPM group, 29% of the Bobath group and 0% of the conventional therapy group.

Conclusion: There is limited evidence (level 2a) from 1 fair quality RCT that task specific reaching is not effective for improving balance post-stroke. However, between-group differences were not reported.

Task-specific reaching
Not Effective
2A

One fair quality RCT (Mudie et al. 2002) has investigated the use of task-specific reaching for balance retraining post-stroke.

The fair quality RCT (Mudie et al., 2002) randomly assigned patients with recent stroke to one of four treatment groups: (1) task-specific reaching; (2) Bobath therapy interventions; (3) BPM biofeedback interventions; or (4) conventional physiotherapy and occupational therapy (control). The task-specific reaching group did not demonstrate a significant improvement in seated weight distribution at post-treatment (2 weeks) or follow-up time points (4 weeks, 12 weeks), whereas all other groups demonstrated significantly improved sitting symmetry at post-treatment. At 12 weeks post-study, 38% of the task-specific reaching group were distributing weight to both sides, as compared to 83% of the BPM group, 29% of the Bobath group and 0% of the conventional therapy group.

Conclusion: There is limited evidence (level 2a) from 1 fair quality RCT that task specific reaching is not effective for improving balance post-stroke. However, between-group differences were not reported.

Thermal therapy
Not Effective
1B

One high quality RCT (Chen et al., 2011) investigated the effect of thermal therapy on balance in patients with stroke.

The high quality RCT (Chen et al., 2011) randomized patients with acute stroke to receive thermal stimulation and conventional rehabilitation or conventional rehabilitation alone. No significant between-group differences in balance (Berg Balance Scale; Postural Assessment Scale for stroke Trunk Control) were seen post-treatment (6 weeks).

Conclusion: There is moderate evidence (level 1b) from 1 high quality RCT that thermal therapy is not more effective than conventional rehabilitation for improving balance in patients with acute stroke.

Trunk exercises
Conflicting
4

Five high quality RCTs (de Seze et al., 2001; Howe et al., 2005; Verheyden et al., 2009; Karthikbabu et al., 2011; Saeys et al., 2011) have investigated the effect of trunk exercises on balance in patients with stroke.

The first high quality RCT (de Seze et al., 2001) randomly assigned patients with stroke to receive trunk control training with visual and auditory feedback using the Bon Saint Come device, or conventional rehabilitation training. Significant between-group differences were noted for balance (Upright Equilibrium Index; Trunk Control Test) at 30 days (post-treatment) and remained at 90 day follow-up (Upright Equilibrium Index only). No significant between-group differences were found for sitting balance (Sitting Equilibrium Index) at post-treatment or follow-up.

The second high quality RCT (Howe et al., 2005) randomized patients with acute stroke to receive lateral weight transference training in sitting and standing and conventional rehabilitation, or conventional rehabilitation alone. There were no significant between-group differences in balance (weight displacement during lateral reaching in sitting and standing; time taken to transfer from sit-to-stand and stand-to-sit) at post-treatment (4 weeks) or follow-up (8 weeks).

The third high quality RCT (Verheyden et al., 2009) randomized patients with acute and subacute stroke to receive conventional rehabilitation and individualized trunk exercises (intervention group) or conventional rehabilitation alone (control group). At 5 weeks (post-treatment) there was a significant between-group difference in dynamic sitting balance (Trunk Impairment Scale dynamic sitting balance), in favour of the intervention group compared to the control group. There were no significant between-group differences on other measures of balance and coordination (Trunk Impairment Scale total, static sitting balance, coordination).

The fourth high quality RCT (Karthikbabu et al., 2011) randomised patients with acute stroke to perform trunk exercises on an unstable surface (intervention group) or on a stable surface (control group), in addition to conventional physiotherapy. At 3 weeks (post-treatment) there were significant between-group differences in balance and coordination (Trunk Impairment Scale [TIS] total, dynamic sitting balance, coordination; Brunel Balance Assessment [BBA] total and stepping subtest scores), in favour of the intervention group compared to the control group. However, no significant between-group differences were seen for static sitting balance (TIS) or standing balance (BBA).

The fifth high quality RCT (Saeys et al., 2011) randomised patients with acute or subacute stroke to receive conventional training and exercises to improve trunk muscle strength, coordination and movement (intervention group), or conventional training and sham treatment that comprised passive mobilization and TENS to the hemiplegic shoulder (control group). At 8 weeks (post-treatment) there were significant differences in balance (Berg Balance Scale; Four Test Balance Scale; Tinetti Test; Trunk Impairment Scale [TIS] total, dynamic sitting, coordination). No significant between-group differences were seen in static sitting balance (TIS static sitting) or proprioception (Romberg tests).

Conclusion: There is conflicting evidence (level 4) among 5 high quality RCTs regarding the effect of trunk exercises on balance following stroke. While studies reported better outcomes than conventional rehabilitation on several balance measures (e.g. Berg Balance Scale, Brunel Balance Assessment, Trunk Control Test, Tinetti Test, Four Test Balance Scale, Upright Equilibrium Index, Trunk Impairment Scale – dynamic balance), all studies also reported no significant between-group differences on other balance measures (Sitting Equilibrium Index, Trunk Impairment Scale – static sitting balance, Romberg tests, weight displacement during lateral reaching, and time taken to transfer between sit and stand).

Note: Most participants were in the acute or subacute stages of stroke recovery. Variation in outcome measures used, as well as the type, frequency and duration of trunk exercises, are likely to account for these differences in outcomes between studies.

Vibration therapy
Not Effective
1B

One high quality RCT (van Nes et al., 2006) and 1 fair quality RCT (Merkert et al., 2011) have investigated the effect of vibration therapy on balance in patients with stroke.

The first high quality RCT (van Nes et al., 2006) randomized patients with subacute stroke to receive whole-body vibration using a commercially-available platform vibration device, or exercise therapy on music at the same frequency and duration (sham stimulation). No significant between-group differences in balance (Berg Balance Scale; Trunk Control Test) were seen at 6 weeks (post-treatment) or 12 weeks (follow-up).

The fair quality RCT (Merkert et al., 2011) randomized patients with stroke to receive balance training and vibration therapy using a Vibrosphere® vibrating platform, or conventional rehabilitation alone. There were no significant differences between groups for balance (Berg Balance Scale) at 15 days (post-treatment).

Conclusion: There is moderate evidence (level 1b) from 1 high quality RCT and 1 fair quality RCT that vibration therapy is not more effective than control therapies (e.g. conventional therapy, sham stimulation) for improving balance following stroke.

Virtual reality
Not Effective
2A

One fair quality RCT (Yang et al., 2011) has investigated the effect of virtual reality training programs on balance in patients following stroke.

The fair quality RCT (Yang et al., 2011) randomised patients with chronic stroke to receive virtual reality treadmill training or traditional treadmill training. Virtual reality treadmill training comprised level walking while watching interactive scenes that simulated turns, whereas the control group completed level treadmill walking with a garden view. At post-treatment (3 weeks) there was a significant between-group difference in center of pressure (COP) displacement in the medial-lateral direction during quiet stance. There were no other significant differences between groups in measures taken in quiet stance or sit-to-stand transfers (COP displacement in the anterior-posterior direction, COP total path excursion, COP sway area, symmetry index, COP path excursion under the paretic limb) or during level walking (stance time of the paretic limb, contact area of the paretic foot, and number of steps of the paretic limb).

Conclusion: There is limited evidence (level 2a) from 1 fair quality RCT that virtual reality treadmill training is not more effective than traditional treadmill training for improving static or dynamic balance in patients following stroke.

Note: However, the fair quality RCT did find a significant between-group difference in COP displacement in the medial-lateral direction during quiet stance, in favour of the virtual reality treadmill training group.

Vision-deprived training
Effective
1B

One high quality RCT (Bonan et al. 2004) has investigated the efficacy of vision-deprived training for the improvement of balance post-stroke.

The high quality RCT (Bonan et al., 2004) randomly assigned patients with stroke to receive vision-deprived training (intervention group) or free vision training (control group). At post-treatment significant between-group differences were noted in balance (Sensory Organization Test), in favour of the intervention group compared to the control group.

Conclusion: There is moderate evidence (level 1b) from 1 high quality RCT that vision-deprived training is more effective than free vision training for improving balance post-stroke.

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Body Weight Supported Treadmill Training

Evidence Reviewed as of before: 23-11-2010
Author(s)*: Angela Kim, BSc; Adam Kagan, BSc; Anita Menon MSc. erg; Robert Teasell; Sanjit Bhogal MSc; Norine Foley BSc; Mark Speechley; Chelsea Hellings; Nicol Korner-Bitensky; Geoffroy Hubert BSc; Geoffroy Hubert BSc. Lic. K
Patient/Family Information Table of contents

Introduction

Restoring walking ability is one of the primary goals of stroke rehabilitation. Failure to walk following a stroke can lead to serious long-term disability. About one-third of individuals surviving an acute stroke are unable to walk three months after being admitted to hospital (Wade et al. 1987). Walking can be affected by residual impairments and disabilities including impaired balance, muscle stiffness, and decreased motor function. One method for retraining walking has been through partial body weight support (BWS) combined with treadmill training. The person is partially suspended in a harness either from the ceiling or from an apparatus frame (see photograph), in order to reduce weight bearing and provide postural support for treadmill walking. The amount of support can be gradually decreased as postural control, balance, and coordination begin to improve.

Patient/Family Information

Author: Marc-André Roy, MSc

What is body weight supported treadmill training?

Body weight supported (BWS) treadmill training is a method for retraining walking. A person using BWS is supported by a harness that is suspended from a metal frame or from the ceiling (see photograph here below). The harness and BWS provide support and reduce the weight on your feet while you walk on the treadmill. The amount of support can be gradually increased or decreased according to your particular needs. For example, if your therapist increases the treadmill speed, you might need more BWS for a short time as you try to keep your balance and posture while walking faster.

Front view of a body weight support system with an overhead suspension and harness that supports the subject on the treadmill.

Body Weight Supported Treadmill

Why use body weight supported treadmill training after a stroke?

Some people have difficulty walking after a stroke. BWS treadmill training may be a safe way for you to begin walking when you are not able to walk safely by yourself. BWS allows some people to start walking earlier after a stroke, especially if they currently require two people to help them walk over ground. It also allows some people to practice walking when they are not ready to do so over ground.

Does it work for stroke?

The best research studies on BWS and treadmill training have shown differing results depending on the severity of the walking deficit. In general, benefits have been found in people who have serious problems walking after a stroke. The benefits are less certain for individuals who only have mild difficulty walking after a stroke.

  • For those with serious walking deficits, a number of high quality research studies have shown that BWS treadmill training is more effective than usual walking training for improving speed of walking, endurance, balance, motor recovery, and functional walking.
  • For those with mild walking deficits, high quality studies have not found that BWS treadmill training is more effective than usual walking training.

What can I expect?

BWS treadmill training is a fairly new treatment. You may be receiving rehabilitation in a setting that has the equipment and if so, you may be offered this treatment. Many different harnesses have been designed to support the body. However, there are some aspects of this intervention that are common to all the equipment used:

  • You will wear a harness over your clothes.
  • The harness is then fastened to an overhead suspension system.
  • The therapist providing the therapy will decide on how much of your body weight is supported by the harness and how much is supported by your legs.
  • When the therapist adjusts the BWS it will feel like you are being lifted slightly off the floor.
  • The therapist will then start the treadmill at a very low speed. The therapist can then increase the speed as your walking ability improves.

Side effects/risks?

There are no specific side effects of BWS treadmill training. In fact, research has shown that it is easier on your heart if you walk with your body weight supported – so after a stroke it may be easier for you to practice walking using BWS as compared to walking over ground.

Generally, people who have used BWS tell us that they feel more confident because they are supported by the harness and can practice walking without the risk of a fall.

However, there are some patients who have told us that they find the harness uncomfortable to wear – and some who do not enjoy walking on a treadmill.

Who provides the treatment?

BWS treadmill training is typically performed by a physical therapist. An assistant may be present to help you get ready by putting on your harness and staying with you during rest periods. This equipment is quite costly and it is quite a labor-intensive treatment, so the rehabilitation center where you are receiving rehabilitation may not have a BWS system. If further research continues to show benefits for those with severe walking difficulties, it is likely that more rehabilitation centers will purchase the equipment.

How many treatments?

The best exercise program design is unknown. However, in most of the studies that have found BWS treadmill training effective, the patients received the therapy 20 to 40 minutes (with rest periods in-between), 4-to-5 days a week, for at least 2 weeks, and sometimes as long as 6 weeks.

How much does it cost? Does insurance pay for it?

In Canada, BWS treadmill training is covered if you are receiving care in a rehabilitation setting that offers this form of treatment. If you are receiving private rehabilitation you will have to verify that your insurance covers the cost of BWS treadmill training.

Is body weight supported treadmill training for me?

If your gait has been seriously affected by a stroke, BWS treadmill training could help you regain endurance, control of your lower limbs, and cardiovascular health. However, further studies are needed to better understand who can benefit most from this type of training.

Clinician Information

Note: When reviewing the findings, it is important to note that they are always made according to randomized clinical trial (RCT) criteria – specifically as compared to a control group. To clarify, if a treatment is “effective” it implies that it is more effective than the control treatment to which it was compared. Non-randomized studies are no longer included when there is sufficient research to indicate strong evidence (level 1a) for an outcome.

Of the 12 studies investigating the effect of BWS treadmill training on gait recovery of patients, eight were fair quality, and two were not scored as they were not RCTs.

A systematic Cochrane review investigating the effectiveness of BWS treadmill training post-stroke concluded that there are no statistically significant differences between patients receiving BWS treadmill training as compared to over-ground gait therapy on functional ambulation and other gait parameters. They did however report that patients who walked independently at baseline showed a trend towards greater improvement than those with more severe impairments (Moseley et al. 2003).

Since that time new studies have found significant post-intervention differences on a number of gait parameters between those who received BWS and those who received treadmill training without BWS.

Only studies that compare BWS treadmill to either overground walking, or treadmill training with no BWS are reviewed in this module. Studies that involve comparisons with electromechanical gait trainers (the “electromechanical gait trainers” involves a harness-secured patient putting his feet on two motorized footplates that simulate stance and swing movements of gait) are presented in the module entitled “Electromechanical gait trainers”.
*Although no significant between-group differences were found, results indicated a potential benefit of using BWS treadmill training compared to other therapies.

Results Table

View results table

Outcomes

Acute Phase of Stroke Recovery

Balance
Not Effective
1B

Results from one high quality RCT (Nilsson et al. 2001) reported no significant difference in balance at post-treatment and at the 10 month follow-up assessment (as assessed by the Berg Balance Scale) between those with acute stroke who received BWS treadmill training or over-ground gait therapy, in addition to their usual therapy.

Conclusion: There is moderate evidence (level 1b) from one high quality RCT that BWS treadmill training does not improve balance during ambulation for acute patients post-stroke.

Endurance
Not Effective
2A

One fair quality RCT (da Cunha IT Jr et al. 2001) involving patients with acute stroke, reported no significant differences in endurance at post-treatment for those who received BWS treadmill training versus over-ground gait therapy – both in addition to usual physical therapy.

Conclusion: There is limited evidence (level 2a) from one fair quality RCT that BWS treadmill training does not improve endurance in patients with an acute stroke.

Functional ambulation
Not Effective
1B

One high quality RCT (Nilsson et al. 2001) and one fair quality RCT(da Cunha IT Jr et al. 2001a) involving patients with an acute stroke receiving either BWS treadmill training or over-ground gait therapy in addition to their usual therapy, have reported no significant differences in functional ambulation between the two groups at post-treatment, as measured by the functional ambulation Categories (FAC). In addition, the study by (Nilsson et al. 2001) found no significant differences between the two groups on the FAC at 10-month follow-up.

Conclusion: There is moderate evidence (level 1b) from one high quality RCT and one fair quality RCT that BWS treadmill training does not improve functional ambulation in patients with an acute stroke.

Functional independence
Not Effective
1B

Results from one high quality RCT (Nilsson et al. 2001) reported no significant difference in activities of daily living as assessed by the Functional Independence Measure (FIM) at post-treatment and at the 10 month follow-up assessment, between acute patients who received BWS treadmill training versus over-ground gait therapy.

Conclusion: There is moderate evidence (level 1b) from one high quality RCT that BWS treadmill training does not improve functional independence in acute stroke.

Motor recovery
Not Effective
1B

Results from one high quality RCT(Nilsson et al. 2001) reported no significant improvements in motor recovery as assessed by the Fugl-Meyer Motor Assessment (FMA) at post-treatment and at 10 month follow-up, for acute patients with a stroke who received BWS treadmill training as compared to over-ground gait therapy.

Conclusion: There is moderate evidence (level 1b) from one high quality RCT that BWS treadmill training does not improve motor recovery in patients with an acute stroke

Walking speed
Not Effective
1B

Results from one high quality RCT (Nilsson et al. 2001) and one fair quality RCT (da Cunha IT Jr et al. 2001) reported no significant difference in walking speed at post-treatment between acute patients with stroke who received BWS treadmill training or over-ground gait therapy. Only 12 subjects were studied by da Cunha IT Jr et al.

Conclusion: There is moderate evidence (level 1b) from one high quality RCT and one fair quality RCT that BWS treadmill training does not improve walking speed in patients with an acute stroke.

Subacute Phase of Stroke Recovery - Low Ambulatory Status

Balance
Effective
1b

One high quality RCT (Visintin et al. 1998) investigated the effect of BWS treadmill training on balance in patients with subacute stroke. The study found significant between-group differences in balance (as measured by the Berg Balance Scale) at post-treatment in favour of patients who received BWS treadmill training as compared to treadmill training without BWS, but these significant differences were not seen at the 3 month follow-up. Further sub-analyses of the data (Barbeau and Visintin (2003) suggested significant differences in balance on the Berg Balance Scale at post-treatment and at 3-month follow-up assessment, in patients with low ambulatory status who received BWS treadmill training as compared to treadmill training without BWS. Such differences were not observed between patients with high ambulatory status in the two groups at post-treatment and at 3-month follow-up.

Conclusion: There is moderate evidence (level 1b) from one high quality RCT that BWS treadmill training is better than overground walking for improving balance in patients with subacute stroke and low initial ambulatory status post-stroke.

Discharge destination
Effective
1B

One high quality RCT (Ada et al. 2010) investigated the effect of BWS treadmill training on discharge destination in patients with low ambulatory status and subacute stroke. Within 6 months, the study found a significant between-group difference in the number of patients who were discharged home or in supported accomodation in favour of the group that received up to 6 months* of BWS treadmill training group compared to a control group that received up to 6 months* of assisted overground walking.
* Patients received up to 6 months training, where training ended at discharge or when the patient was able to walk unassisted for 15 meters.
Note: Fewer patients in intervention group required assisted accommodation following discharge.

Conclusion: There is moderate evidence (level 1b) from 1 high quality RCT that BWS treadmill training improves the number of patients discharged to their home environments, compared to assisted overground walking in patients with subacute stroke and low ambulatory status.

Functional ambulation
Not Effective
1B

One high quality RCT (Franceschini et al., 2009) has investigated the effect of BWS treadmill training on functional ambulation in patients with subacute stroke.

The high quality RCT (Franceschini et al., 2009) randomized patients with subacute stroke to an intervention group that received BWS treadmill training or a control group that received overground gait training. No significant difference in functional ambulation (as measured by the functional ambulation Categories) was found at 2 weeks (mid-intervention), 4 weeks (post-intervention), 6 weeks (follow-up) or at 6 months post-stroke.

Conclusion: There is moderate evidence (level 1b) from one high quality RCT that BWS treadmill training is not more effective than overground gait training in improving functional ambulation in patients with subacute stroke.

Functional independence
Not Effective
1B

One high quality RCT